The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease.

IF 0.7 4区医学 Q4 PATHOLOGY Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-25 DOI:10.1080/15513815.2024.2306280

Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan

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Abstract

Introduction: We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC).

Methods: Thirty cases (M:27, F:3) operated on due to HD. The cases were divided into three groups: group 1 with pre and post operative EC, group 2 with post-operative, and group 3 with pre-operative EC. The intestinal segments were evaluated by immunohistochemistry for interleukin 1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6).

Results: IL-1β staining was significantly higher in the ganglionic zone of groups with enterocolitis compared to the control group (p = 0.012). TNF-α staining in the transitional zone of Group 3 and IL-1β staining in the ganglionic zone of Group 1 was significantly higher than the control group (p = 0.030, p = 0.020).

Conclusion: In our study, older age at diagnosis and more than 20% IL-1ß staining in the ganglionic segment were found to be risk factors for HAEC. It is noteworthy that the increase in IL-1ß can be associated with HAEC.

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神经节段炎症反应对赫氏肠病术后小肠结肠炎的影响

简介我们研究了在赫氏脓肿病（HD）和赫氏脓肿相关性小肠结肠炎（HAEC）肠道炎症反应中出现的促炎细胞因子之间的关系：方法：30 例（男：27 例，女：3 例）因 HD 而接受手术的病例。方法：30 例（男：27 例，女：3 例）因 HD 而接受手术的病例被分为三组：第一组为术前和术后 EC，第二组为术后 EC，第三组为术前 EC。用免疫组化方法对肠段的白细胞介素1β（IL-1ß）、肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）进行评估：结果：与对照组相比，肠炎组神经节区的 IL-1β 染色率明显更高（p = 0.012）。第3组过渡区的TNF-α染色和第1组神经节区的IL-1β染色明显高于对照组（P = 0.030，P = 0.020）：我们的研究发现，诊断时年龄较大和神经节段 IL-1ß 染色超过 20% 是 HAEC 的危险因素。值得注意的是，IL-1ß的增加可能与HAEC有关。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.