Intravitreal Brolucizumab for Chronic Central Serous Chorioretinopathy without Choroidal Neovascular Membrane - a Pilot Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-11-01 Epub Date: 2024-01-25 DOI:10.1080/08820538.2024.2308808

Srishti Raksheeth Ramamurthy, Umesh Chandra Behera, Ritesh Narula, SriniVas R Sadda, Raja Narayanan

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Abstract

Purpose: To study intravitreal brolucizumab in the management of persistent macular fluid in chronic central serous chorioretinopathy (CSCR) without choroidal neovascular membrane (CNVM).

Methods: Retrospective case series which included eyes with chronic CSCR with persistent macular fluid for ≥ 3 months without CNVM. Intravitreal brolucizumab was administered in all eyes. Primary outcome measure was the resolution of intraretinal (IRF) and/or subretinal fluid (SRF) on OCT.

Results: Five eyes (four patients) with chronic CSCR were included. All eyes showed complete resolution of SRF 1 month following injection. Minimal residual IRF was present in two eyes. Best corrected visual acuity (BCVA) was stable in three eyes, and two eyes showed improvement. Central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) showed reduction.

Conclusion: Intravitreal brolucizumab is effective in the rapid reduction of persistent macular fluid in chronic CSCR without CNVM. Long-term follow-up data are required to study recurrence and adverse effect profile.

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无脉络膜新生血管膜的慢性中心性浆液性脉络膜视网膜病变的玻璃体内布卢单抗--一项试验性研究。

目的：研究玻璃体内布鲁珠单抗治疗无脉络膜新生血管膜（CNVM）的慢性中心性浆液性脉络膜视网膜病变（CSCR）持续性黄斑积液的方法：方法：回顾性病例系列，包括持续黄斑积液≥3个月且无脉络膜新生血管膜的慢性中央型浆液性脉络膜视网膜病变患者。所有眼球均接受了玻璃体内注射肉毒杆菌。主要结果指标为 OCT 上视网膜内积液（IRF）和/或视网膜下积液（SRF）的消退情况：结果：共纳入五只患有慢性 CSCR 的眼睛（四名患者）。注射后 1 个月，所有患者的 SRF 均完全消退。两只眼睛存在轻微的残留 IRF。三只眼的最佳矫正视力（BCVA）保持稳定，两只眼有所改善。黄斑中心厚度（CMT）和眼底脉络膜厚度（SFCT）均有所下降：结论：对于无 CNVM 的慢性 CSCR，玻璃体内注射肉毒杆菌能有效快速减少持续性黄斑积液。需要长期随访数据来研究复发和不良反应情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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