Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-06-01 Epub Date: 2024-01-25 DOI:10.1007/s11154-023-09872-8
Heraldo M Garmes
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Abstract

Pituitary hormone deficiency, hypopituitarism, is a dysfunction resulting from numerous etiologies, which can be complete or partial, and is therefore heterogeneous. This heterogeneity makes it difficult to interpret the results of scientific studies with these patients.Adequate treatment of etiologies and up-to-date hormone replacement have improved morbidity and mortality rates in patients with hypopituitarism. As GH replacement is not performed in a reasonable proportion of patients, especially in some countries, it is essential to understand the known consequences of GH replacement in each subgroup of patients with this heterogeneous dysfunction.In this review on hypopituitarism, we will address some particularities regarding insulin resistance, which is no longer common in these patients with hormone replacement therapy based on current guidelines, metabolic syndrome and its relationship with changes in BMI and body composition, and to vascular complications that need to be prevented taking into account the individual characteristics of each case to reduce mortality rates in these patients.

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垂体功能减退患者的胰岛素抵抗、代谢综合征和血管并发症专题。
垂体激素缺乏症(垂体功能减退症)是一种由多种病因导致的功能障碍,可以是完全性的,也可以是部分性的,因此具有异质性。对病因的充分治疗和最新的激素替代改善了垂体功能减退症患者的发病率和死亡率。由于没有对相当一部分患者进行 GH 替代治疗,尤其是在一些国家,因此有必要了解 GH 替代治疗对患有这种异质性功能障碍的各个亚组患者的已知后果。在这篇关于垂体功能减退症的综述中,我们将讨论胰岛素抵抗的一些特殊性(根据现行指南,胰岛素抵抗在接受激素替代治疗的患者中已不再常见)、代谢综合征及其与体重指数(BMI)和身体成分变化的关系,以及血管并发症,这些并发症需要根据每个病例的个体特征加以预防,以降低这些患者的死亡率。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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