Huali YANG , Minghui DENG , Hongwei JIA , Kaicheng ZHANG , Yang LIU , Maosheng CHENG , Wei XIAO
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引用次数: 0
Abstract
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
齐墩果酸（OA）是一种五环三萜类化合物，具有广泛的生物活性，包括抗肿瘤、抗病毒、抗菌、抗炎、保肝、降血糖和降血脂作用。自最初分离和鉴定 OA 及其衍生物以来，已有大量关于其结构修饰和药理活性的研究报告。尽管如此，在过去的二十年中，有关 OA 的全面综述并不多见，这给后续研究带来了挑战。本文基于 OA 的主要生物活性，全面总结了 OA 及其衍生物的修饰策略和结构-活性关系（SARs），为今后 OA 的研究提供有价值的参考。
期刊介绍：
The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM).
Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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