Simultaneous and sensitive detection of dopamine and acetaminophen at a glassy carbon electrode modified with a carbonized-ZIF-67/Super P nanocomposite†
{"title":"Simultaneous and sensitive detection of dopamine and acetaminophen at a glassy carbon electrode modified with a carbonized-ZIF-67/Super P nanocomposite†","authors":"Xiaobo Li, Kaifeng Yang, Fangming Han, Yafeng Jin, Haonan Zhang and Heng Gao","doi":"10.1039/D3NJ05135H","DOIUrl":null,"url":null,"abstract":"<p >The coexistence of dopamine (DA) and acetaminophen (AC) in living organisms leading to an unexpected mutual interference in electrochemical detection techniques demands a simultaneous, selective as well as simple and cost-effective approach for DA and AC. Herein, a novel nanocomposite was fabricated by integrating carbonized ZIF-67 (C-ZIF-67) with carbon black <em>Super P</em> (SP) and introduced onto a glassy carbon electrode (GCE) to form a highly sensitive electrochemical sensor (C-ZIF-67/SP/GCE) for the simultaneous determination of DA and AC. The well-prepared nanomaterial presents a polyhedral morphology interlaced on a reticulated chain. C-ZIF-67/SP/GCE shows excellent electrocatalytic activity towards the redox reactions of DA and AC in a dynamic linear range up to 100 μM, which could be attributed to the synergistic effect of the large specific surface area of C-ZIF67 and the excellent conductivity of SP. The limits of detection (LODs, S/N = 3) of 0.58 μM and 0.27 μM were obtained for DA and AC, respectively. Moreover, the developed sensor exhibited good reproducibility and long-term stability. The C-ZIF-67/SP/GCE was employed to analyze DA and AC biomedical samples and satisfactory recoveries were achieved. This approach provides a simple, easy and sensitive method to detect DA and AC simultaneously and selectively.</p>","PeriodicalId":95,"journal":{"name":"New Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj05135h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The coexistence of dopamine (DA) and acetaminophen (AC) in living organisms leading to an unexpected mutual interference in electrochemical detection techniques demands a simultaneous, selective as well as simple and cost-effective approach for DA and AC. Herein, a novel nanocomposite was fabricated by integrating carbonized ZIF-67 (C-ZIF-67) with carbon black Super P (SP) and introduced onto a glassy carbon electrode (GCE) to form a highly sensitive electrochemical sensor (C-ZIF-67/SP/GCE) for the simultaneous determination of DA and AC. The well-prepared nanomaterial presents a polyhedral morphology interlaced on a reticulated chain. C-ZIF-67/SP/GCE shows excellent electrocatalytic activity towards the redox reactions of DA and AC in a dynamic linear range up to 100 μM, which could be attributed to the synergistic effect of the large specific surface area of C-ZIF67 and the excellent conductivity of SP. The limits of detection (LODs, S/N = 3) of 0.58 μM and 0.27 μM were obtained for DA and AC, respectively. Moreover, the developed sensor exhibited good reproducibility and long-term stability. The C-ZIF-67/SP/GCE was employed to analyze DA and AC biomedical samples and satisfactory recoveries were achieved. This approach provides a simple, easy and sensitive method to detect DA and AC simultaneously and selectively.
多巴胺(DA)和对乙酰氨基酚(AC)在生物体内共存,会对电化学检测技术产生意想不到的相互干扰,因此需要一种同时、选择性、简单且经济高效的方法来检测多巴胺和对乙酰氨基酚。在此,通过将碳化 ZIF-67 (C-ZIF-67) 与碳黑 Super P (SP) 相结合,制备了一种新型纳米复合材料,并将其引入玻璃碳电极 (GCE),形成了一种高灵敏度的电化学传感器 (C-ZIF-67/SP/GCE),用于同时测定 DA 和 AC。制备好的纳米材料呈现出网状链上多面体交错的形态。C-ZIF-67/SP/GCE 在高达 100 µM 的动态线性范围内对 DA 和 AC 的氧化还原反应表现出优异的电催化活性,这可能归功于 C-ZIF67 的大比表面积和 SP 的优异导电性的协同效应。DA 和 AC 的检测限(LOD,S/N=3)分别为 0.58 µM 和 0.27 µM。此外,所开发的传感器还具有良好的重现性和长期稳定性。C-ZIF-67/SP/GCE 被用来分析 DA 和 AC 生物医学样品,并获得了令人满意的回收率。这种方法为同时选择性地检测 DA 和 AC 提供了一种简单、方便和灵敏的方法。