Jielong Wu , Jie Fang , Xiaodong Yuan , Lingshan Ma , Liangcheng Zheng , Qing Lin , Xingkai An , Zhanxiang Wang , Qilin Ma
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Abstract
Aim
We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM.
Methods
Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine. In addition, a cross-sectional study including 168 migraine patients was conducted in Xiamen, China. Migraine patients were grouped according to their T2DM status. Multivariable linear regression models were used to estimate βs and their 95% CIs for the relationship between migraine characteristics and T2DM.
Results
The cumulative incidence rate of migraine from 2015 to 2018 in the T2DM group and control group was 7.26% [6.04%.8.65%] and 8.91% [8.27%.9.58%], respectively. The risk of migraine in patients with T2DM was reduced by 21% (HR 0.79 [0.65;0.95]) compared to patients with no T2DM after adjustment for confounders. The cross-sectional study showed that the presence of T2DM significantly reduced migraine frequency and relieved migraine intensity.
Conclusion
This was the first study to validate that T2DM reduced the risk of migraine in a Chinese population cohort. Patients with migraine and T2DM may experience significant relief from their headache symptoms. Carrying out relevant mechanistic research may help to identify new targets for migraine treatment and contribute to further understanding the impact of T2DM or related metabolic disorders on an individual's health.
AimWe aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM.Methods研究队列9873人的数据来自中国健康与退休纵向研究（CHARLS）。评估了2015年至2018年偏头痛的发病率。采用Cox比例危险模型估计T2DM与偏头痛发病率之间关系的危险比（HRs）及其95%置信区间（CIs）。此外，还在中国厦门开展了一项横断面研究，纳入了168名偏头痛患者。偏头痛患者根据其 T2DM 状态进行分组。结果2015年至2018年，T2DM组和对照组偏头痛的累计发病率分别为7.26% [6.04%.8.65%]和8.91% [8.27%.9.58%]。在对混杂因素进行调整后，T2DM患者发生偏头痛的风险比未患T2DM的患者降低了21%（HR为0.79 [0.65;0.95]）。这项横断面研究表明，T2DM 可显著降低偏头痛发生频率，缓解偏头痛强度。偏头痛合并 T2DM 患者的头痛症状可能会明显缓解。开展相关的机理研究有助于确定偏头痛治疗的新靶点，并有助于进一步了解T2DM或相关代谢紊乱对个人健康的影响。
期刊介绍：
A high quality scientific journal with an international readership
Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing.
Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
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