Remnant cholesterol as a new lipid-lowering target to reduce cardiovascular events.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in lipidology Pub Date : 2024-06-01 Epub Date: 2024-01-23 DOI:10.1097/MOL.0000000000000921

Paolo Raggi, Maria Laura Becciu, Eliano P Navarese

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Abstract

Purpose of review: Remnant cholesterol has become increasingly recognized as a direct contributor to the development of atherosclerosis and as an additional marker of cardiovascular risk. This review aims to summarize the pathophysiological mechanisms, and the current evidence base from epidemiological investigations and genetic studies that support a causal link between remnant cholesterol and atherosclerotic cardiovascular disease. Current and novel therapeutic approaches to target remnant cholesterol are discussed.

Recent findings: A recent Mendelian randomization study of over 12 000 000 single-nucleotide polymorphisms associated with high levels of remnant cholesterol, demonstrated a genetic association between remnant cholesterol and adverse cardiovascular events among 958 434 participants.

Summary: In this light, the emerging role of remnant cholesterol as an independent lipid risk marker warrants a reevaluation of lipid management guidelines and underscores the potential for novel therapeutic targets in cardiovascular disease prevention.

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残余胆固醇是减少心血管事件的新降脂目标。

综述的目的：人们日益认识到，残余胆固醇是动脉粥样硬化的直接诱因，也是心血管风险的额外标志。本综述旨在总结病理生理学机制，以及目前流行病学调查和遗传学研究支持残余胆固醇与动脉粥样硬化性心血管疾病之间存在因果关系的证据基础。此外，还讨论了针对残余胆固醇的当前和新型治疗方法：摘要：有鉴于此，残余胆固醇作为一种独立的血脂风险标志物的作用正在显现，因此有必要重新评估血脂管理指南，并强调新型治疗目标在预防心血管疾病方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.