A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects.

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0113895575273335231128080705
Wen-Jun Wei, Dong-Ge Wang, Meng-Shan Ji, Tao Guo
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Abstract

Medicinal insects play an important role in the treatment of refractory diseases due to their unique and rich pharmacological activities. However, compared to plants, microorganisms, and marine organisms, medicinal insects have been largely ignored. Some small molecules isolated from insects are known to have defensive effects, but their majority roles remain unknown. In-depth research on the small molecules of medicinal insects has been conducted in recent years. Then alkaloids, dopamine derivatives, nucleoside derivatives, and other components are obtained. Among them, dopamine derivatives are a unique class of components from medicinal insects. Thus, we present a comprehensive overview of chemical structures and biological activities of dopamine derivatives from some medicinal insects, which will bring more attention to other researchers for further chemical and biological investigations on the unique dopamine derivatives as well as medicinal insects.

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药用昆虫多巴胺衍生物的化学结构和生物活性综述。
药用昆虫具有独特而丰富的药理活性,在治疗难治性疾病方面发挥着重要作用。然而,与植物、微生物和海洋生物相比,药用昆虫在很大程度上被忽视了。已知从昆虫中分离出的一些小分子具有防御作用,但它们的主要作用仍不为人知。近年来,人们对药用昆虫的小分子物质进行了深入研究。其中,多巴胺衍生物、核苷衍生物和其他成分被广泛应用于昆虫药用小分子化合物的研究中。其中,多巴胺衍生物是药用昆虫中一类独特的成分。因此,我们对一些药用昆虫中的多巴胺衍生物的化学结构和生物活性进行了全面的综述,这将引起其他研究人员的更多关注,以便对独特的多巴胺衍生物以及药用昆虫进行进一步的化学和生物学研究。
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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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