{"title":"Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry","authors":"David L. Hughes*, ","doi":"10.1021/acs.oprd.3c00438","DOIUrl":null,"url":null,"abstract":"<p >Flow chemistry reactions and continuous separations have become established processing modalities in the pharmaceutical industry from early development to manufacturing. The current review highlights patents and patent applications from 2019 to 2023 wherein no accompanying journal article has been published, with a focus on examples that enable chemistries that are difficult or unsafe to scale in batch mode or provide significant process intensification.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"28 5","pages":"1272–1287"},"PeriodicalIF":3.1000,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00438","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Flow chemistry reactions and continuous separations have become established processing modalities in the pharmaceutical industry from early development to manufacturing. The current review highlights patents and patent applications from 2019 to 2023 wherein no accompanying journal article has been published, with a focus on examples that enable chemistries that are difficult or unsafe to scale in batch mode or provide significant process intensification.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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