Effect of spermidine on long non-coding RNAs MALAT1 in a rotenone induced-rat model of Parkinson's disease

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY Fundamental & Clinical Pharmacology Pub Date : 2024-01-26 DOI:10.1111/fcp.12986

Noha Mohamed Badae, Doaa A. Abdelmonsif, Rania Gaber Aly, Amira M. Omar, Mai S. Shoela, Eman M. Omar

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Abstract

Background

Spermidine is a natural biologically active substance that has widespread influences on the body.

Objective

This study aims to enhance our understanding of the potential effect of spermidine on long non-coding RNA MALAT1 and explore the underlying mechanism in the rotenone-induced rat model of Parkinson's disease.

Methods

Rats were sacrificed after locomotor behavioral testing. Striatal tissues were used to assess the expression of MALAT1, oxidative stress markers, and autophagy markers.

Results

Our study found that treatment with spermidine for 2 weeks during the induction of the model significantly improved behavioral assessment, dopamine levels, and attenuated the histopathological changes that occurred in PD in comparison to the non-treated group.

Conclusion

Our preliminary study supports the protective effect of spermidine on the activation of autophagy and its antioxidant properties. Part of the antioxidant activity is due to the inhibition of MALAT1. However, MALAT1 does not correlate with the spermidine-induced autophagy pathway.

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在鱼藤酮诱导的帕金森病大鼠模型中，亚精胺对长非编码 RNA MALAT1 的影响

背景：精胺是一种天然生物活性物质，对人体具有广泛的影响：本研究旨在进一步了解亚精胺对长非编码 RNA MALAT1 的潜在影响，并探讨其在鱼藤酮诱导的帕金森病大鼠模型中的作用机制：方法：大鼠在运动行为测试后被处死。方法：大鼠在运动行为测试后被处死，纹状体组织用于评估 MALAT1、氧化应激标记物和自噬标记物的表达：我们的研究发现，在诱导模型期间使用亚精胺治疗 2 周，与未治疗组相比，可显著改善行为评估和多巴胺水平，并减轻帕金森病的组织病理学变化：我们的初步研究证实了亚精胺对自噬激活的保护作用及其抗氧化特性。部分抗氧化活性是由于抑制了 MALAT1。然而，MALAT1与亚精胺诱导的自噬途径并不相关。

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.