Standardization and Pharmacological Evaluation of Ziziphus mauritiana Extract for Sedative and Anticonvulsant Activity in Mice and Rat.

Nadim Siddique, Akash Ved, Karuna Shanker Shukla, Amit Kumar Nigam
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Abstract

Introduction: Ziziphus mauritiana, sometimes called Indian jujube or Ber, belongs to the Rhamnaceae group of plants. The aqueous and ethanolic Ziziphus mauritiana formulations were shown to have analgesic, antipyretic, potent analgesic, anti-inflammatory, and anti-emetic properties.

Aims & objectives: The aim of this study is to investigate the sedative and anticonvulsant activities of Ziziphus mauritiana extract by governing 200 and 400 mg/kg body weight orally.

Materials and methods: The leaves are extracted with ethanol and lukewarm water with a soxhlet apparatus for 72 hours. After that acute extract toxicity study was performed and then locomotor activity, pentobarbital induced sleeping time and anticonvulsant activity were performed with the extract.

Results: Oral administration of extract at dosages of 200 & 400 mg/kg was employed after an immediate toxicity test. At a dosage of 400 mg/kg, the number of locomotions was reduced significantly lengthened the period of time spent sleeping and there was showed a dosage-dependent reduction in all phases of an epileptic episode.

Conclusion: In this study, the extract reduced locomotor activity, however, it had a superior profile for an antiepileptic action than phenytoin since it decreased locomotor activity to a lesser level. The considerable increase in pentobarbitone sleep hours with the extracts at a higher dose supported the sedative action of Z. mauritiana.

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毛地黄提取物在小鼠和大鼠中镇静和抗惊厥活性的标准化和药理学评价
简介毛酸枣(Ziziphus mauritiana),有时也被称为印度枣或浆果,属于鼠李科植物。研究表明,毛酸枣水溶液和乙醇制剂具有镇痛、解热、强效镇痛、抗炎和止吐的特性:本研究的目的是通过口服 200 毫克和 400 毫克/千克体重的剂量,研究毛地黄提取物的镇静和抗惊厥活性:用乙醇和温水在索氏提取器中萃取叶片72小时。然后进行急性提取物毒性研究,并对该提取物的运动活性、戊巴比妥诱导的睡眠时间和抗惊厥活性进行研究:结果:在立即毒性试验后,口服 200 和 400 毫克/千克剂量的提取物。结果:经过即时毒性试验后,以 200 毫克/千克和 400 毫克/千克的剂量口服提取物,运动次数明显减少,睡眠时间明显延长,癫痫发作的所有阶段都出现了剂量依赖性减少:结论:在这项研究中,提取物降低了运动活动,但它的抗癫痫作用优于苯妥英,因为它降低运动活动的程度较低。较高剂量的提取物可显著增加戊巴比妥的睡眠时间,这支持了毛果芸香碱的镇静作用。
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