Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats.

Ismail Bouadid, Adil Qabouche, Mohamed Eddouks
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Abstract

Aims: The antihypertensive activity of Daphne gnidium was tested.

Background: Daphne gnidium (Thymelaeaceae) is used against hypertension.

Objective: The antihypertensive effect of Daphne gnidium was evaluated in this study.

Methods: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.

Results: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.

Conclusion: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.

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Daphne gnidium 对大鼠的降压和 ACE-2 抑制作用
目的:测试水飞蓟的抗高血压活性:背景:Daphne gnidium(百日草科)可用于治疗高血压:本研究评估了钩藤的降压作用:方法:评估钩藤水提取物(DGAE,100 和 180 mg/kg)对大鼠血压的影响。此外,还测试了该提取物的血管舒张作用:结果:DGAE 可降低高血压大鼠的血压,并具有舒张血管的活性。此外,DGAE 的累积浓度可通过受体激活钙通道(ROCCs)诱导血管扩张,而不会影响 ACE-2:结论:Daphne gnidium 的水提取物具有抗高血压活性,并能通过抑制 Ca2+ 进入诱导血管扩张。
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