Transformation or replacement - Effects of hormone therapy on cardiovascular risk

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-02-01 DOI:10.1016/j.pharmthera.2024.108592
Julia Kielb , Süreyya Saffak , Jessica Weber , Leonard Baensch , Khatereh Shahjerdi , Aylin Celik , Nora Farahat , Sally Riek , Oscar Chavez-Talavera , Maria Grandoch , Amin Polzin , Malte Kelm , Lisa Dannenberg
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Abstract

Hormone therapy (HT) is important and frequently used both regarding replacement therapy (HRT) and gender affirming therapy (GAHT). While HRT has been effective in addressing symptoms related to hormone shortage, several side effects have been described. In this context, there are some studies that show increased cardiovascular risk. However, there are also studies reporting protective aspects of HT. Nevertheless, the exact impact of HT on cardiovascular risk and the underlying mechanisms remain poorly understood. This article explores the relationship between diverse types of HT and cardiovascular risk, focusing on mechanistic insights of the underlying hormones on platelet and leukocyte function as well as on effects on endothelial and adipose tissue cells.

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转变或替代 - 激素疗法对心血管风险的影响
激素疗法(HT)对于替代疗法(HRT)和性别平权疗法(GAHT)都很重要,也经常使用。虽然激素替代疗法能有效解决与激素短缺有关的症状,但也出现了一些副作用。在这方面,一些研究显示心血管风险增加。不过,也有研究报告称,激素替代疗法具有保护作用。然而,人们对激素对心血管风险的确切影响及其内在机制仍然知之甚少。本文探讨了各种类型的高血压与心血管风险之间的关系,重点是从机理上揭示潜在激素对血小板和白细胞功能的影响,以及对内皮细胞和脂肪组织细胞的影响。
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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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