The effect of local dexamethasone on stapedotomy surgery outcomes in patients with otosclerosis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-01-27 DOI:10.1080/00016489.2024.2304062

Mohammad Mandegari, Mojtaba Meybodian, Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Mahmood Vakili, Saeedeh Dehghanifirouzabadi

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Abstract

Background: Some studies have shown a positive effect of systemic corticosteroid on hearing results after stapedotomy, but its side effects can limit its routine administration.

Aim: The aim of this study was to investigate the effect of local dexamethasone on the results of stapedotomy surgery.

Material and methods: Fifty two patients undergone stapedotomy surgery for otosclerosis involved. In the case group after stapedotomy we fulfilled the middle ear with dexamethasone and then the placement of the prosthesis was done. In the control group after stapedotomy we did not use dexamethasone in the middle ear.

Results: Gender, age, nausea, vomiting, postoperative vertigo and nystagmus did not significantly differ between the groups. A significant difference was observed in tinnitus rate between two groups. In the case group ABG decrease was higher and bone conduction thresholds improved at frequencies of 1000, 2000, and 4000 three months after surgery.

Conclusion: Since local dexamethasone had a positive effect on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery's success rate.

Significance: If local dexamethasone had a positive influence on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery's success rate.

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局部地塞米松对耳硬化症患者镫骨切开术疗效的影响

背景：目的：本研究旨在探讨局部地塞米松对镫骨手术效果的影响：52例因耳硬化症接受镫骨手术的患者。在镫骨切除术后的病例组中，我们用地塞米松填充中耳，然后植入假体。对照组在镫骨切除术后，我们没有在中耳使用地塞米松：结果：各组之间在性别、年龄、恶心、呕吐、术后眩晕和眼球震颤方面没有显著差异。两组间耳鸣发生率有明显差异。病例组的 ABG 下降率更高，术后三个月，频率分别为 1000、2000 和 4000 的骨传导阈值有所改善：结论：由于局部地塞米松对镫骨切除手术的效果有积极影响，因此可以用来代替全身皮质类固醇，以减少副作用，提高手术成功率：意义：如果局部地塞米松对镫骨切开术的效果有积极影响，则可用于替代全身皮质类固醇，以减少副作用，提高手术成功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.