Neoadjuvant therapy for resectable melanoma.

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2024-01-28 DOI:10.1007/s10585-023-10263-1
Cimarron E Sharon, Giorgos C Karakousis
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Abstract

The standard of care for patients with resectable stage III/IV melanoma classically included upfront resection with adjuvant therapy. However, in more recent years, the amount of systemic therapies available for neoadjuvant use for these patients has increased. This article reviewed clinical trials investigating neoadjuvant therapy for patients with resectable stage III/IV melanoma. The outcomes of these trials have identified optimal treatment regimens to maximise patient response and minimize toxicities. Additionally, the date demonstrate advantages to neoadjuvant treatment compared to adjuvant therapy alone. Further research is needed to utilize a patient's response to neoadjuvant treatment for prognostication and creation of an individualized treatment plan.

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可切除黑色素瘤的新辅助治疗。
可切除的 III/IV 期黑色素瘤患者的传统治疗标准包括前期切除和辅助治疗。然而,近年来,可用于这些患者新辅助治疗的系统性疗法数量有所增加。本文回顾了针对可切除III/IV期黑色素瘤患者进行新辅助治疗的临床试验。这些试验的结果确定了最佳治疗方案,以最大限度地提高患者的反应和减少毒性。此外,试验结果还证明了新辅助治疗比单纯辅助治疗更有优势。还需要进一步研究如何利用患者对新辅助治疗的反应来预测预后和制定个体化治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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