A genomics perspective of personalized prevention and management of obesity.

IF 3.8 3区医学 Q2 GENETICS & HEREDITY Human Genomics Pub Date : 2024-01-29 DOI:10.1186/s40246-024-00570-3

Kalliopi K Gkouskou, Maria G Grammatikopoulou, Evgenia Lazou, Theodora Vasilogiannakopoulou, Despina Sanoudou, Aristides G Eliopoulos

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Abstract

This review discusses the landscape of personalized prevention and management of obesity from a nutrigenetics perspective. Focusing on macronutrient tailoring, we discuss the impact of genetic variation on responses to carbohydrate, lipid, protein, and fiber consumption. Our bioinformatic analysis of genomic variants guiding macronutrient intake revealed enrichment of pathways associated with circadian rhythm, melatonin metabolism, cholesterol and lipoprotein remodeling and PPAR signaling as potential targets of macronutrients for the management of obesity in relevant genetic backgrounds. Notably, our data-based in silico predictions suggest the potential of repurposing the SYK inhibitor fostamatinib for obesity treatment in relevant genetic profiles. In addition to dietary considerations, we address genetic variations guiding lifestyle changes in weight management, including exercise and chrononutrition. Finally, we emphasize the need for a refined understanding and expanded research into the complex genetic landscape underlying obesity and its management.

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从基因组学角度看肥胖症的个性化预防和管理。

这篇综述从营养遗传学的角度探讨了个性化预防和管理肥胖症的前景。我们以宏量营养素定制为重点，讨论了基因变异对碳水化合物、脂类、蛋白质和纤维摄入反应的影响。我们对指导宏量营养素摄入的基因组变异进行的生物信息学分析表明，与昼夜节律、褪黑激素代谢、胆固醇和脂蛋白重塑以及 PPAR 信号转导相关的通路丰富起来，成为相关遗传背景下宏量营养素控制肥胖症的潜在靶点。值得注意的是，我们基于数据的硅学预测表明，SYK抑制剂福斯塔替尼有可能被重新用于相关遗传背景下的肥胖症治疗。除了饮食方面的考虑，我们还探讨了指导体重管理中生活方式改变的基因变异，包括运动和长期营养。最后，我们强调有必要深入了解肥胖症及其管理背后复杂的基因情况，并扩大研究范围。

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来源期刊

Human Genomics GENETICS & HEREDITY-

CiteScore

6.00

自引率

2.20%

发文量

审稿时长

11 weeks

期刊介绍： Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.