A systematic review and meta-analysis of protozoan parasite infections among patients with mental health disorders: an overlooked phenomenon.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Pathogens Pub Date : 2024-01-28 DOI:10.1186/s13099-024-00602-2

Amir Abdoli, Meysam Olfatifar, Aida Vafae Eslahi, Zeinab Moghadamizad, Rasoul Samimi, Mohammad Amin Habibi, Amir Sam Kianimoghadam, Milad Badri, Panagiotis Karanis

{"title":"A systematic review and meta-analysis of protozoan parasite infections among patients with mental health disorders: an overlooked phenomenon.","authors":"Amir Abdoli, Meysam Olfatifar, Aida Vafae Eslahi, Zeinab Moghadamizad, Rasoul Samimi, Mohammad Amin Habibi, Amir Sam Kianimoghadam, Milad Badri, Panagiotis Karanis","doi":"10.1186/s13099-024-00602-2","DOIUrl":null,"url":null,"abstract":"Background: Patients with mental disorders have a high risk of intestinal parasitic infection due to poor hygiene practices. Hence, to better clarify this overlooked phenomenon, the current study is conducted to determine the global prevalence of protozoan parasite infections in patients with mental disorders and investigate the associated risk factors.Methods: Several databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched for papers published until December 2022. The fixed effect meta-analysis was used to estimate the overall odds ratio (OR) and pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI).Results: Totally, 131 articles (91 case-control and 40 cross-sectional studies) met the eligibility criteria. Patients with mental disorders were significantly at higher risk for protozoan parasites than healthy controls (OR: 2.059, 1.830-2.317). The highest pooled OR (2.485, 1.413-4.368) was related to patients with neurodevelopmental disorders, and the highest pooled prevalence was detected in patients with neurodevelopmental disorders (0.341, 0.244-0.446), followed by bipolar and related disorders (0.321, 0.000-0.995). Toxoplasma gondii was the most prevalent protozoan parasite (0.343, 0.228-0.467) in cross-sectional studies and the highest pooled OR was related to Cyclospora cayetanensis (4.719, 1.352-16.474) followed by Cryptosporidium parvum (4.618, 2.877-7.412).Conclusion: Our findings demonstrated that individuals afflicted with mental disorders are significantly more susceptible to acquiring protozoan parasites in comparison to healthy individuals. Preventive interventions, regular screening, and treatment approaches for parasitic diseases should be considered for patients with mental disorders.","PeriodicalId":12833,"journal":{"name":"Gut Pathogens","volume":"16 1","pages":"7"},"PeriodicalIF":4.3000,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822187/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Pathogens","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13099-024-00602-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Patients with mental disorders have a high risk of intestinal parasitic infection due to poor hygiene practices. Hence, to better clarify this overlooked phenomenon, the current study is conducted to determine the global prevalence of protozoan parasite infections in patients with mental disorders and investigate the associated risk factors.

Methods: Several databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched for papers published until December 2022. The fixed effect meta-analysis was used to estimate the overall odds ratio (OR) and pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI).

Results: Totally, 131 articles (91 case-control and 40 cross-sectional studies) met the eligibility criteria. Patients with mental disorders were significantly at higher risk for protozoan parasites than healthy controls (OR: 2.059, 1.830-2.317). The highest pooled OR (2.485, 1.413-4.368) was related to patients with neurodevelopmental disorders, and the highest pooled prevalence was detected in patients with neurodevelopmental disorders (0.341, 0.244-0.446), followed by bipolar and related disorders (0.321, 0.000-0.995). Toxoplasma gondii was the most prevalent protozoan parasite (0.343, 0.228-0.467) in cross-sectional studies and the highest pooled OR was related to Cyclospora cayetanensis (4.719, 1.352-16.474) followed by Cryptosporidium parvum (4.618, 2.877-7.412).

Conclusion: Our findings demonstrated that individuals afflicted with mental disorders are significantly more susceptible to acquiring protozoan parasites in comparison to healthy individuals. Preventive interventions, regular screening, and treatment approaches for parasitic diseases should be considered for patients with mental disorders.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

精神疾病患者原生动物寄生虫感染的系统回顾和荟萃分析：一个被忽视的现象。

背景：由于卫生习惯差，精神障碍患者感染肠道寄生虫的风险很高。因此，为了更好地澄清这一被忽视的现象，本研究旨在确定精神障碍患者原生动物寄生虫感染的全球流行率，并调查相关的风险因素：检索了多个数据库（PubMed、Scopus、Web of Science、ProQuest 和 Google Scholar）中截至 2022 年 12 月发表的论文。采用固定效应荟萃分析法估算总体几率比（OR），并采用随机效应模型估算汇总患病率，得出95%的置信区间（CI）：共有 131 篇文章（91 项病例对照研究和 40 项横断面研究）符合资格标准。精神障碍患者感染原生动物寄生虫的风险明显高于健康对照组（OR：2.059，1.830-2.317）。神经发育障碍患者的综合 OR 值最高（2.485，1.413-4.368），神经发育障碍患者的综合感染率最高（0.341，0.244-0.446），其次是双相情感障碍和相关障碍（0.321，0.000-0.995）。在横断面研究中，弓形虫是最常见的原生动物寄生虫（0.343，0.228-0.467），与环孢子虫有关的集合OR值最高（4.719，1.352-16.474），其次是副隐孢子虫（4.618，2.877-7.412）：我们的研究结果表明，与健康人相比，精神障碍患者更容易感染原生动物寄生虫。应考虑对精神障碍患者进行寄生虫病的预防干预、定期筛查和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).