Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health.

IF 4.3 2区医学 Current Osteoporosis Reports Pub Date : 2024-02-01 Epub Date: 2024-01-29 DOI:10.1007/s11914-023-00847-x

Sonali J Karnik, Tyler J Margetts, Hannah S Wang, Alexandru Movila, Adrian L Oblak, Jill C Fehrenbacher, Melissa A Kacena, Lilian I Plotkin

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Abstract

Purpose of review: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in an aging population.

Recent findings: Aging intensifies both ADRD and bone deterioration. Notably, ADRD patients have a heightened fracture risk, impacting morbidity and mortality, though it is uncertain if fractures worsen ADRD. Therapeutically, agents targeting inflammation pathways, especially Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and TNF-α, appear beneficial for both conditions. Additionally, treatments like Sirtuin 1 (SIRT-1), known for anti-inflammatory and neuroprotective properties, are gaining attention. The interconnectedness of AD/ADRD and bone health necessitates a unified treatment approach. By addressing shared mechanisms, we can potentially transform therapeutic strategies, enriching our understanding and refining care in our aging society. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.

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注意差距：揭开阿尔茨海默氏症和相关痴呆症与骨骼健康之间错综复杂的关系。

综述的目的：这篇综述探讨了阿尔茨海默病/相关痴呆症（AD/ADRD）与骨质疏松症等骨科疾病之间的病理生理学联系。重点是 "炎症"--两者共同的低水平炎症及其对老龄人口的影响：最新发现：衰老会加剧老年痴呆症和骨质退化。值得注意的是，ADRD 患者骨折风险增加，影响发病率和死亡率，但骨折是否会加重 ADRD 还不确定。在治疗上，针对炎症通路，尤其是活化 B 细胞核因子卡巴轻链增强因子（NF-kB）和 TNF-α 的药物似乎对这两种疾病都有好处。此外，以抗炎和神经保护特性著称的 Sirtuin 1（SIRT-1）等疗法也越来越受到关注。注意力缺失综合症/注意力缺失性障碍与骨骼健康之间的相互关联需要一种统一的治疗方法。通过研究共同的机制，我们有可能改变治疗策略，丰富我们对老龄化社会的理解并改善护理。这篇综述文章是多篇系列稿件的一部分，旨在确定使用人工智能撰写科学综述的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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