A meta-analysis of melanoma risk in idiopathic inflammatory myopathy patients.

IF 0.9 4区医学 Q4 RHEUMATOLOGY Zeitschrift fur Rheumatologie Pub Date : 2024-12-01 Epub Date: 2024-01-29 DOI:10.1007/s00393-024-01473-3

Rui Luo, Dan Xia, Siyang Yu

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Abstract

Background: Idiopathic inflammatory myopathy (IIM) is a group of chronic acquired autoimmune diseases. The association between IIM and malignancies has been observed for decades. No meta-analysis has been conducted to summarize the relationship between IIM and melanoma. Herein, we specifically wanted to investigate whether IIM is associated with a higher incidence of melanoma.

Methods: We searched both Chinese and English databases (CNKI, VIP, Wanfang, PubMed, Embase, Web of Science) for studies on IIM related to melanoma published up to October 2023. Two independent authors reviewed all literature to identify studies according to predefined selection criteria. Fixed effects models were applied to pool the risk. Publication bias was also evaluated and sensitivity analysis performed.

Results: A total of 1660 articles were initially identified but only four cohort studies met the criteria. Thus, 4239 IIM patients were followed up. The pooled overall risk ratio/hazard ratio was 3.08 (95% confidence interval [CI] 0.79-5.37) and the standardized incidence ratio was 6.30 (95% CI 1.59-11.02).

Conclusion: The present meta-analysis suggests that IIM patients are at a significantly higher risk of developing melanoma.

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特发性炎症性肌病患者黑色素瘤风险的荟萃分析。

背景：特发性炎症性肌病（IIM）是一组慢性获得性自身免疫性疾病。几十年来，人们一直在观察特发性炎症性肌病与恶性肿瘤之间的关系。目前还没有荟萃分析总结 IIM 与黑色素瘤之间的关系。在此，我们特别想研究 IIM 是否与黑色素瘤的高发病率有关：我们检索了中英文数据库（CNKI、VIP、万方、PubMed、Embase、Web of Science）中截至 2023 年 10 月发表的与黑色素瘤相关的 IIM 研究。两位独立作者对所有文献进行了审查，以根据预定的筛选标准确定研究。采用固定效应模型对风险进行汇总。同时还评估了发表偏倚并进行了敏感性分析：最初共确定了 1660 篇文章，但只有四项队列研究符合标准。因此，共有 4239 名 IIM 患者接受了随访。汇总的总风险比/危险比为 3.08（95% 置信区间 [CI]：0.79-5.37），标准化发病比为 6.30（95% 置信区间 [CI]：1.59-11.02）：本荟萃分析表明，IIM 患者罹患黑色素瘤的风险明显更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift fur Rheumatologie 医学-风湿病学

CiteScore

2.20

自引率

20.00%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Die Zeitschrift für Rheumatologie ist ein international angesehenes Publikationsorgan und dient der Fortbildung von niedergelassenen und in der Klinik tätigen Rheumatologen. Die Zeitschrift widmet sich allen Aspekten der klinischen Rheumatologie, der Therapie rheumatischer Erkrankungen sowie der rheumatologischen Grundlagenforschung. Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht dabei gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit – der Leser erhält konkrete Handlungsempfehlungen. Frei eingereichte Originalien ermöglichen die Präsentation wichtiger klinischer Studien und dienen dem wissenschaftlichen Austausch.