Lack of Association Between Depression and Subclinical Hypothyroidism in Adolescents Presenting for Routine Physical Examinations.

IF 1.7 Q2 PEDIATRICS Clinical Medicine Insights-Pediatrics Pub Date : 2024-01-27 eCollection Date: 2024-01-01 DOI:10.1177/11795565231220503
Mohan Kumaratne, Franck Vigneron, Jasmine Cisneros, Vinodh Rajapakse
{"title":"Lack of Association Between Depression and Subclinical Hypothyroidism in Adolescents Presenting for Routine Physical Examinations.","authors":"Mohan Kumaratne, Franck Vigneron, Jasmine Cisneros, Vinodh Rajapakse","doi":"10.1177/11795565231220503","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There are conflicting results in the existing studies regarding the association between depression and subclinical hypothyroidism in adolescents. Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone (TSH) levels above the reference range without signs or symptoms of hypothyroidism.</p><p><strong>Objectives: </strong>The focus of this study is to determine whether there is any association between depression and subclinical hypothyroidism, (as defined by the serum TSH levels) in a population of healthy adolescents.</p><p><strong>Design: </strong>Quantitative-based cross-sectional study of a representative subset of the adolescent population.</p><p><strong>Methods: </strong>We carried out a cross-sectional study to determine the association between major depressive disorder (MDD) and subclinical hypothyroidism, in adolescents presenting for annual physical examinations during the peak period of the COVID-19 pandemic in the USA, a period deemed high for adolescent depression. All the adolescents were screened for depression by the PHQ-9 screening tool and had their TSH measured.</p><p><strong>Results: </strong>Of the 304 subjects analyzed, 179 (58.88%) were minimally or not depressed according to the Patient Health Questionnaire (PHQ-9) screening tool (mean PHQ 1.80 ± 1.49). 70 (23.03%) had mild depression (mean PHQ 6.59 ± 1.46), 50 (16.45%) had moderate depression (mean PHQ 13.70 ± 2.75), and 5 (1.64%) had severe depression (mean PHQ 21.40 ± 1.67). Mean TSH values were 1.93 ± 0.99, 1.77 ± 1.05, 2.10 ± 0.98, and 1.57 ± 0.32 mIU/L, respectively in the four groups. All values were within the recommended range of 0.50 to 4.30 mIU/L, without statistically significant inter-group differences.</p><p><strong>Conclusion: </strong>We conclude that there is no statistically significant association between depression and subclinical hypothyroidism, in a population of adolescents presenting for physical examinations, and if the screening for depression by the PHQ-9 tool indicates depression, a screening TSH test for subclinical hypothyroidism is not justified.</p>","PeriodicalId":45027,"journal":{"name":"Clinical Medicine Insights-Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822073/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine Insights-Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11795565231220503","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: There are conflicting results in the existing studies regarding the association between depression and subclinical hypothyroidism in adolescents. Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone (TSH) levels above the reference range without signs or symptoms of hypothyroidism.

Objectives: The focus of this study is to determine whether there is any association between depression and subclinical hypothyroidism, (as defined by the serum TSH levels) in a population of healthy adolescents.

Design: Quantitative-based cross-sectional study of a representative subset of the adolescent population.

Methods: We carried out a cross-sectional study to determine the association between major depressive disorder (MDD) and subclinical hypothyroidism, in adolescents presenting for annual physical examinations during the peak period of the COVID-19 pandemic in the USA, a period deemed high for adolescent depression. All the adolescents were screened for depression by the PHQ-9 screening tool and had their TSH measured.

Results: Of the 304 subjects analyzed, 179 (58.88%) were minimally or not depressed according to the Patient Health Questionnaire (PHQ-9) screening tool (mean PHQ 1.80 ± 1.49). 70 (23.03%) had mild depression (mean PHQ 6.59 ± 1.46), 50 (16.45%) had moderate depression (mean PHQ 13.70 ± 2.75), and 5 (1.64%) had severe depression (mean PHQ 21.40 ± 1.67). Mean TSH values were 1.93 ± 0.99, 1.77 ± 1.05, 2.10 ± 0.98, and 1.57 ± 0.32 mIU/L, respectively in the four groups. All values were within the recommended range of 0.50 to 4.30 mIU/L, without statistically significant inter-group differences.

Conclusion: We conclude that there is no statistically significant association between depression and subclinical hypothyroidism, in a population of adolescents presenting for physical examinations, and if the screening for depression by the PHQ-9 tool indicates depression, a screening TSH test for subclinical hypothyroidism is not justified.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在接受常规体检的青少年中,抑郁与亚临床甲状腺机能减退症之间没有关联。
背景:关于青少年抑郁症与亚临床甲状腺功能减退症之间的关系,现有研究的结果相互矛盾。亚临床甲状腺机能减退的定义是促甲状腺激素(TSH)水平升高超过参考范围,但没有甲状腺机能减退的症状或体征:本研究的重点是确定在健康青少年群体中,抑郁症与亚临床甲状腺机能减退(由血清促甲状腺激素水平定义)之间是否存在任何关联:设计:对具有代表性的青少年群体进行基于定量的横断面研究:我们开展了一项横断面研究,以确定在美国 COVID-19 大流行的高峰期(青少年抑郁症的高发期)接受年度体检的青少年中,重度抑郁症(MDD)与亚临床甲状腺机能减退之间的关联。所有青少年都通过 PHQ-9 筛查工具进行了抑郁症筛查,并测量了他们的促甲状腺激素:在分析的 304 名受试者中,179 人(58.88%)根据患者健康问卷(PHQ-9)筛查工具(平均 PHQ 1.80 ± 1.49)属于轻度抑郁或无抑郁。70人(23.03%)患有轻度抑郁症(平均PHQ为6.59 ± 1.46),50人(16.45%)患有中度抑郁症(平均PHQ为13.70 ± 2.75),5人(1.64%)患有重度抑郁症(平均PHQ为21.40 ± 1.67)。四组患者的 TSH 平均值分别为 1.93 ± 0.99、1.77 ± 1.05、2.10 ± 0.98 和 1.57 ± 0.32 mIU/L。所有数值均在 0.50 至 4.30 mIU/L 的推荐范围内,组间差异无统计学意义:我们得出的结论是,在接受体检的青少年群体中,抑郁症与亚临床甲减之间没有统计学意义上的显著关联,如果通过PHQ-9工具筛查出抑郁症,则不需要进行亚临床甲减的TSH筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
5
审稿时长
8 weeks
期刊最新文献
Giant Congenital Ovarian Cyst Presenting as an Abdominal Mass. Influencing Factors on Independent Walking in Children With Lumbosacral Lipomas: A Retrospective Cohort Study Based on a 5-Year Untethering Series. Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies. Assessment of Voiding Dysfunction and Nocturnal Enuresis Rates in Primary School Children in Nablus, Palestine: A Cross-Sectional Study. A Multi-Center Retrospective Database Evaluation of Pediatric Subjects Diagnosed With Methemoglobinemia.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1