Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI:10.1097/WAD.0000000000000607

Gina M D'Souza, Nathan W Churchill, Dylan X Guan, Marc A Khoury, Simon J Graham, Sanjeev Kumar, Corinne E Fischer, Tom A Schweizer

{"title":"Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness.","authors":"Gina M D'Souza, Nathan W Churchill, Dylan X Guan, Marc A Khoury, Simon J Graham, Sanjeev Kumar, Corinne E Fischer, Tom A Schweizer","doi":"10.1097/WAD.0000000000000607","DOIUrl":null,"url":null,"abstract":"Introduction: Traumatic brain injury (TBI) is associated with an accelerated course of dementia, although biological relationships are incompletely understood.Methods: The study examined 1124 participants, including 343 with Alzheimer disease (AD), 127 with AD with TBI, 266 cognitively normal adults with TBI, and 388 cognitively normal adults without TBI. Cortical thickness was quantified from T1-weighted magnetic resonance imaging data. Multiple linear regression was used to determine the interaction between AD and TBI on cortical thickness.Results: Among those with AD, TBI was associated with an earlier age of AD onset but, counterintuitively, less cortical thinning in frontotemporal regions relative to non-AD controls.Discussion: AD with TBI represents a distinct group from AD, likely with distinct pathologic contributions beyond gray matter loss. This finding has important implications for the diagnosis and treatment of AD in the presence of TBI and indicates that models of AD, aging, and neural loss should account for TBI history.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer Disease & Associated Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/WAD.0000000000000607","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Traumatic brain injury (TBI) is associated with an accelerated course of dementia, although biological relationships are incompletely understood.

Methods: The study examined 1124 participants, including 343 with Alzheimer disease (AD), 127 with AD with TBI, 266 cognitively normal adults with TBI, and 388 cognitively normal adults without TBI. Cortical thickness was quantified from T1-weighted magnetic resonance imaging data. Multiple linear regression was used to determine the interaction between AD and TBI on cortical thickness.

Results: Among those with AD, TBI was associated with an earlier age of AD onset but, counterintuitively, less cortical thinning in frontotemporal regions relative to non-AD controls.

Discussion: AD with TBI represents a distinct group from AD, likely with distinct pathologic contributions beyond gray matter loss. This finding has important implications for the diagnosis and treatment of AD in the presence of TBI and indicates that models of AD, aging, and neural loss should account for TBI history.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

阿尔茨海默病和脑外伤对皮质厚度的相互作用

导言：创伤性脑损伤（TBI）与痴呆症的加速病程有关，但其生物学关系尚不完全清楚：该研究对1124名参与者进行了检查，其中包括343名阿尔茨海默病（AD）患者、127名患有TBI的AD患者、266名患有TBI的认知正常成人以及388名未患有TBI的认知正常成人。皮质厚度通过 T1 加权磁共振成像数据进行量化。多元线性回归用于确定注意力缺失症和创伤性脑损伤对皮质厚度的交互作用：结果：在 AD 患者中，TBI 与 AD 发病年龄较早有关，但与非 AD 对照组相比，TBI 与额颞部皮质厚度较薄有关，这与直觉相反：讨论：伴有创伤性脑损伤的注意力缺失症是与注意力缺失症不同的一个群体，除了灰质丢失外，可能还有其他不同的病理因素。这一发现对存在创伤性脑损伤的注意力缺失症的诊断和治疗具有重要意义，并表明注意力缺失症、衰老和神经损失模型应考虑创伤性脑损伤史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.