Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-11-01 Epub Date: 2024-01-29 DOI:10.1097/PGP.0000000000001017
Dalia M Badary, Huda Elsaied, Mahmoud R Abdel-Fadeil, Mohammed K Ali, Hisham Abou-Taleb, Heba M Iraqy
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Abstract

Summary: Netrin-1, an epithelial-secreted protein, plays a key role in placental formation through the promotion of cytotrophoblast proliferation and placental vascular development. These effects are mediated through several receptors, including the deleted in colorectal cancer (DCC) receptor. Placenta accreta spectrum (PAS) is an exaggerated trophoblastic invasion into the uterine myometrium. The exact etiology is unknown, but it is believed that increased trophoblastic invasion, defect decidualization, and/or abnormal angiogenesis might play a role. Our study aimed to investigate the suggested role of macrophage-induced netrin-1/DCC/vascular endothelial growth factor (VEGF) signaling in PAS pathogenesis. A total of 29 women with PAS (as cases) and 29 women with normal pregnancies (as controls) were enrolled in the study. At delivery, placental tissues of both groups were collected and processed for the evaluation of placental netrin-1 level by enzyme-linked immunoassay technique and immunohistochemical analysis of tissue DCC receptor. Placental tissue netrin-1 level of PAS cases showed a statistically significantly higher value than those in the normal group. Significant overexpression of DCC receptors, VEGF, and enhanced macrophage recruitment was noted in PAS cases in comparison to the normal placenta. Macrophage-induced netrin-1/DCC/VEGF signaling might be involved in PAS pathogenesis through the enhancement of trophoblastic angiogenesis.

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结直肠癌/血管内皮生长因子信号通路中的内皮素-1/Deleted在胎盘早剥谱发病机制中的可能作用:病例对照研究。
摘要:Netrin-1 是一种上皮分泌的蛋白质,通过促进细胞母细胞增殖和胎盘血管发育,在胎盘形成过程中发挥关键作用。这些作用是通过几种受体介导的,包括大肠癌(DCC)受体。胎盘早剥谱系(PAS)是滋养细胞侵入子宫肌层的一种夸张现象。确切的病因尚不清楚,但据认为滋养细胞侵袭增加、蜕膜化缺陷和/或血管生成异常可能是其中的一个原因。我们的研究旨在探讨巨噬细胞诱导的网织蛋白-1/DCC/血管内皮生长因子(VEGF)信号传导在PAS发病机制中的作用。研究共纳入了 29 名 PAS 孕妇(作为病例)和 29 名正常妊娠孕妇(作为对照)。分娩时,收集并处理两组孕妇的胎盘组织,通过酶联免疫测定技术评估胎盘净蛋白-1的水平,并对组织DCC受体进行免疫组化分析。PAS病例的胎盘组织网织蛋白-1水平明显高于正常组,差异有统计学意义。与正常胎盘相比,PAS 病例中的 DCC 受体、血管内皮生长因子和巨噬细胞募集均明显过表达。巨噬细胞诱导的netrin-1/DCC/VEGF信号可能通过增强滋养细胞血管生成参与了PAS的发病机制。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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