Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Psychiatric Genetics Pub Date : 2024-04-01 Epub Date: 2024-01-23 DOI:10.1097/YPG.0000000000000357

Yuqing Song, Yi Zhao, Ancha Baranova, Hongbao Cao, Weihua Yue, Fuquan Zhang

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Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two neurodevelopmental disorders that often result in individuals experiencing traumatic events. However, little is known about the connection between ADHD/ASD and post-traumatic stress disorder (PTSD). This study aimed to investigate the genetic associations between these disorders.

Methods: Genetic correlation analysis was used to examine the genetic components shared between ADHD (38 691 cases and 275 986 controls), ASD (18 381 cases and 27 969 controls) and PTSD (23 212 cases and 151 447 controls). Two-sample Mendelian randomization analyses were employed to explore the bidirectional causal relationships between ADHD/ASD and PTSD.

Results: The results of the genetic correlation analysis revealed significant positive correlations of PTSD with ADHD(r g = 0.70) and ASD (r g = 0.34). Furthermore, the Mendelian randomization analysis revealed that genetic liabilities to ADHD [odds ratio (OR) = 1.14; 95% confidence interval (CI), 1.06-1.24; P = 7.88 × 10 -4 ] and ASD (OR = 1.04; CI, 1.01-1.08; P = 0.014) were associated with an increased risk of developing PTSD later in life. However, no evidence supported that genetic liability to PTSD could elevate the risk of ADHD or ASD.

Conclusion: The findings of this study supported that ADHD and ASD may increase the risk of PTSD, but not vice versa.

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注意缺陷/多动症和自闭症谱系障碍与创伤后应激障碍的因果关系。

背景：注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）是两种神经发育障碍，通常会导致患者经历创伤事件。然而，人们对ADHD/ASD与创伤后应激障碍（PTSD）之间的关系知之甚少。本研究旨在调查这些疾病之间的遗传关联：遗传相关性分析用于研究多动症（38 691 例病例和 275 986 例对照）、自闭症（18 381 例病例和 27 969 例对照）和创伤后应激障碍（23 212 例病例和 151 447 例对照）之间的共同遗传成分。研究人员采用双样本孟德尔随机分析法探讨了ADHD/ASD与创伤后应激障碍之间的双向因果关系：遗传相关性分析结果显示，创伤后应激障碍与多动症（rg = 0.70）和自闭症（rg = 0.34）呈显著正相关。此外，孟德尔随机分析表明，ADHD [几率比（OR）= 1.14；95% 置信区间（CI），1.06-1.24；P = 7.88 × 10-4]和 ASD [几率比（OR）= 1.04；CI，1.01-1.08；P = 0.014]的遗传责任与日后患创伤后应激障碍的风险增加有关。然而，没有证据表明创伤后应激障碍的遗传易感性会增加患多动症或自闭症的风险：本研究结果表明，多动症和自闭症可能会增加创伤后应激障碍的发病风险，但反之亦然。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.