Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-06-01 DOI:10.5935/1518-0557.20240003
Víctor Hugo Gómez, Cristina Rodríguez-Varela, Elena Labarta, Ernesto Bosch
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Abstract

Objective: To analyze if partial premature ovulation (PPO) detection during oocyte pick-up (OPU) impairs the quality of the retrieved oocyte cohort.

Methods: The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a retrospective analysis performed in an infertility clinic (Spain) during 2016-2021 with patients undergoing OPU after controlled ovarian hyperstimulation for an in vitro fertilization (IVF) treatment. Study code: 2110-VLC-091- VG, registered on December 9 2021. Data from women with PPO (n=111) were compared to a matched control sample of cycles without PPO (n=333) at a proportion of 1:3.

Results: Cycles were matched for age, body mass index (BMI), treatment year, embryo genetic analysis and stimulation protocol type. The mean numbers of oocytes (6.1 vs. 11.2), mature oocytes (4.7 vs. 8.8), correctly fertilized oocytes (3.6 vs. 6.6) and top-quality blastocysts (0.9 vs. 1.8) were significantly lower in the PPO group than the nonPPO group (p<0.05). However, maturation, fertilization, top-quality blastocyst and pregnancy rates were statistically comparable among groups (p>0.05).

Conclusions: Cycles with PPO have fewer available oocytes and, thus, fewer available embryos for transfer, al though their quality is intact, and still offer chances of pregnancy in these cases. Hence cycle cancellation may not be worth associated money, time and morale losses once PPO is detected.

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在卵泡抽吸过程中检测到部分过早排卵会影响体外受精(IVF)周期中提取的卵母细胞的数量,但不会影响其质量。
目的分析在卵母细胞拾取术(OPU)中检测到的部分过早排卵(PPO)是否会影响拾取到的卵母细胞群的质量:PPO 概念指的是仅在部分卵泡中发生过早排卵,并在 OPU 期间被检测到的情况。本研究是一项回顾性分析,于2016-2021年间在一家不孕症诊所(西班牙)进行,研究对象为接受体外受精(IVF)治疗的患者,在控制卵巢过度刺激后接受OPU治疗。研究代码2110-VLC-091- VG,于 2021 年 12 月 9 日注册。将患有卵巢功能亢进症的妇女(n=111)的数据与未患有卵巢功能亢进症的匹配对照样本(n=333)的数据进行比较,两者的比例为1:3:结果:各周期的年龄、体重指数(BMI)、治疗年份、胚胎遗传分析和刺激方案类型均匹配。PPO 组的平均卵母细胞数(6.1 对 11.2)、成熟卵母细胞数(4.7 对 8.8)、正确受精卵母细胞数(3.6 对 6.6)和优质囊胚数(0.9 对 1.8)均显著低于非 PPO 组(P0.05):有 PPO 的周期可用卵母细胞较少,因此可移植的胚胎也较少,尽管其质量完好,但在这些情况下仍有怀孕的机会。因此,一旦检测到 PPO,取消周期可能会造成金钱、时间和士气上的损失,得不偿失。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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