Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-02-01 DOI:10.1016/j.pharmthera.2024.108595
Simone Filardo , Mattioli Roberto , Daniel Di Risola , Luciana Mosca , Marisa Di Pietro , Rosa Sessa
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Abstract

Over the years, health challenges have become increasingly complex and global and, at the beginning of the 21st century, chronic diseases, including cardiovascular, neurological, and chronic respiratory diseases, as well as cancer and diabetes, have been identified by World Health Organization as one of the biggest threats to human health. Recently, antimicrobial resistance has also emerged as a growing problem of public health for the management of infectious diseases. In this scenario, the exploration of natural products as supplementation or alternative therapeutic options is acquiring great importance, and, among them, the olive tree, Olea europaea L, specifically leaves, fruits, and oil, has been increasingly investigated for its health promoting properties. Traditionally, these properties have been largely attributed to the high concentration of monounsaturated fatty acids, although, in recent years, beneficial effects have also been associated to other components, particularly polyphenols. Among them, the most interesting group is represented by Olea europaea L secoiridoids, comprising oleuropein, oleocanthal, oleacein, and ligstroside, which display anti-inflammatory, antioxidant, cardioprotective, neuroprotective and anticancer activities. This review provides an overview of the multiple health beneficial effects, the molecular mechanisms, and the potential applications of secoiridoids from Olea europaea L.

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油橄榄 L-萃取琥珀酰糖苷:有益健康的作用和潜在的治疗方法
多年来,健康挑战变得日益复杂和全球化,21 世纪初,慢性疾病,包括心血管、神经和慢性呼吸道疾病,以及癌症和糖尿病,已被世界卫生组织确定为人类健康的最大威胁之一。近来,抗菌药耐药性也已成为公共卫生中日益严重的传染病管理问题。在这种情况下,探索天然产品作为补充或替代疗法正变得越来越重要,其中,橄榄树(Olea europaea L),特别是叶子、果实和橄榄油,因其促进健康的特性而受到越来越多的研究。传统上,这些特性主要归功于高浓度的单不饱和脂肪酸,但近年来,其他成分,特别是多酚也产生了有益的影响。其中,最令人感兴趣的是油橄榄仲呋喃类化合物,包括油茶素、油茶醛、油茶甙和ligstroside,它们具有抗炎、抗氧化、保护心脏、保护神经和抗癌的作用。这篇综述概述了油橄榄中的呫吨类化合物对健康的多种益处、分子机制和潜在应用。
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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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