Neutrophil extracellular trap formation linked to idiopathic pulmonary fibrosis severity and survival

Scott M. Matson, Linh T. Ngo, Yui Sugawara, Veani Fernando, Claudia Lugo, Imaan Azeem, Alexis Harrison, Alex Alsup, Emily Nissen, Devin Koestler, Michael P. Washburn, Michaella J. Rekowski, Paul J. Wolters, Joyce S. Lee, Joshua J. Solomon, M. Kristen Demoruelle
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Abstract

Rationale Neutrophil counts in bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis are associated with worse outcomes; however, the underlying mechanisms are unknown. Neutrophil extracellular trap formation is associated with worse outcomes in several chronic lung diseases however, there is an unknown role in idiopathic pulmonary fibrosis.
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中性粒细胞胞外捕获物的形成与特发性肺纤维化的严重程度和存活率有关
理论依据 特发性肺纤维化支气管肺泡灌洗液中的中性粒细胞计数与预后恶化有关,但其潜在机制尚不清楚。中性粒细胞胞外捕获物的形成与多种慢性肺部疾病的预后恶化有关,但在特发性肺纤维化中的作用尚不清楚。
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