{"title":"1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents","authors":"Yildiz Uygun Cebeci, Sengul Alpay Karaoglu","doi":"10.2174/0115701786270260231215101046","DOIUrl":null,"url":null,"abstract":": In this study, synthesis of 1,2,4 triazo1e-fluoroquino1one hybrid compounds was rea1ized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of a11 synthesized compounds. The antimicrobia1 activities of a11 compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.","PeriodicalId":18116,"journal":{"name":"Letters in Organic Chemistry","volume":"66 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0115701786270260231215101046","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
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Abstract
: In this study, synthesis of 1,2,4 triazo1e-fluoroquino1one hybrid compounds was rea1ized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of a11 synthesized compounds. The antimicrobia1 activities of a11 compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.
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Aims & Scope
Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.
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