Celecoxib Catalyzed the Coupling Reaction of Epoxide and CO2

Abstract

: In this study, high yields of various cyclic carbonates were obtained by employing the drug celecoxib to promote the coupling reaction of CO2 and epoxide using tetrabutylammonium bromide. This strategy enabled the synthesis of benzoic acid, phenylpropiolic acid, and 2, 4- quinazolinedione. In addition, the model reaction mechanism was proposed. background: Cyclic carbonates have a high economic value and broad application as intermediate in fine chemicals, monomers for synthesizing active polymers, polar aprotic solvents in organic reactions and electrolytes in lithium-ion batteries.