Construction of a Miniaturized Electrochemical Sensor for Voltammetric Detection of 17β-Estradiol using a g-C3N4-Decorated Gold Nanoparticles Electrode

IF 1.7 4区化学 Q3 CHEMISTRY, ANALYTICAL Current Analytical Chemistry Pub Date : 2024-01-29 DOI:10.2174/0115734110292025240119112208

Yue Ma, Xuqiao Liu, Kai Yan, Jingdong Zhang

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Abstract

Background: 17β-estradiol (E2) is a steroid hormone that has the potential to disrupt the endocrine system, leading to adverse effects on both humans and ecosystems, even when present in low concentrations. The quantitative determination of E2 is of great practical significance. Hypothesis: Electrochemical methods offer several advantages, including low cost, ease of operation, and potential for miniaturization, which makes them suitable for on-field detection applications. Methods: This research developed a miniaturized electrochemical sensor utilizing graphitic carbon nitride (g-C3N4) assembled on an AuNPs/ITO film electrode for sensitive voltammetric detection of a steroid hormone, E2. Results: Compared with AuNPs/ITO electrodes, the g-C3N4/AuNPs/ITO exhibits higher sensitivity for voltammetric detection of E2. Under optimal conditions, the differential pulse voltammetric response on the g-C3N4/AuNPs/ITO electrode was proportional to E2 concentration in the 25 ~ 600 µmol/L range, with a detection limit of 6.5 µmol/L. Conclusion: The proposed g-C3N4/AuNPs/ITO electrode exhibited a wide linear range, good selectivity, and practical applicability for determining E2 in environmental water samples with acceptable recovery.

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利用 g-C3N4 装饰金纳米粒子电极构建用于伏安法检测 17β 雌二醇的微型电化学传感器

背景：17β-雌二醇（E2）是一种类固醇激素，即使浓度很低，也有可能扰乱内分泌系统，从而对人类和生态系统产生不利影响。定量测定 E2 具有重要的现实意义。假设电化学方法具有成本低、操作简便、可微型化等优点，适合现场检测应用。方法：本研究利用组装在 AuNPs/ITO 薄膜电极上的石墨氮化碳（g-C3N4）开发了一种微型电化学传感器，用于灵敏地伏安法检测类固醇激素 E2。结果：与 AuNPs/ITO 电极相比，g-C3N4/AuNPs/ITO 对 E2 的伏安检测具有更高的灵敏度。在最佳条件下，g-C3N4/AuNPs/ITO 电极上的差分脉冲伏安响应与 25 ~ 600 µmol/L 范围内的 E2 浓度成正比，检测限为 6.5 µmol/L。结论所提出的 g-C3N4/AuNPs/ITO 电极在测定环境水样中的 E2 浓度方面具有线性范围宽、选择性好、回收率可接受等特点。

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来源期刊

Current Analytical Chemistry 化学-分析化学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

9 months

期刊介绍： Current Analytical Chemistry publishes full-length/mini reviews and original research articles on the most recent advances in analytical chemistry. All aspects of the field are represented, including analytical methodology, techniques, and instrumentation in both fundamental and applied research topics of interest to the broad readership of the journal. Current Analytical Chemistry strives to serve as an authoritative source of information in analytical chemistry and in related applications such as biochemical analysis, pharmaceutical research, quantitative biological imaging, novel sensors, and nanotechnology.