β-Lactam Susceptibility of Streptococcus dysgalactiae subsp. equisimilis

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Japanese journal of infectious diseases Pub Date : 2024-01-31 DOI:10.7883/yoken.jjid.2023.339
Natsumi Nakashima, Wanchun Jin, Jun-ichi Wachino, Shinobu Koyama, Kiyoko Tamai, Yoshichika Arakawa, Kouji Kimura
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Abstract

All clinical isolates of Streptococcus dysgalactiae subsp. equisimilis (SDSE) are considered susceptible to β-lactams, the first-line drugs used for SDSE infections. However, penicillin-non-susceptible SDSE has been reported from Denmark. In this study, we attempted to detect β-lactam-non-susceptible clinical isolates of SDSE in Japan. One hundred and fifty clinical isolates of S. dysgalactiae were collected in 2018, and species identification was performed using Rapid ID Strep API. The minimum inhibitory concentrations (MIC) of six β-lactams (penicillin G, oxacillin, ceftizoxime, ceftibuten, cefoxitin, and cefaclor) were determined for 85 clinical isolates of SDSE using the agar dilution method standardized by the Clinical Laboratory Standards Institute. For the 85 isolates identified as SDSE, the MIC ranges of penicillin G, oxacillin, ceftizoxime, ceftibuten, cefoxitin, and cefaclor were 0.007–0.06, 0.03–0.12, 0.015–0.06, 0.25–2, 0.12–2, and 0.06–0.5 μg/mL, respectively. None of the clinical isolates were non-susceptible to penicillin G, indicating that all 85 clinical isolates of SDSE were susceptible to β-lactams. Our findings indicate that almost all clinical isolates of SDSE in several prefectures of Japan remain susceptible to β-lactams. Nevertheless, there remains a need for continuous and careful monitoring of drug susceptibility among clinical isolates of SDSE in Japan.

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对β-内酰胺类药物敏感的赤痢链球菌马氏亚种
所有临床分离的赤痢链球菌马氏亚种(SDSE)都被认为对β-内酰胺类药物敏感,而β-内酰胺类药物是治疗 SDSE 感染的一线药物。然而,丹麦也有对青霉素不敏感的 SDSE 的报道。在本研究中,我们试图检测日本的不耐受β-内酰胺的 SDSE 临床分离株。2018 年收集了 150 例痢疾杆菌临床分离株,并使用 Rapid ID Strep API 进行了菌种鉴定。采用临床实验室标准研究所标准化的琼脂稀释法,测定了85株SDSE临床分离株对6种β-内酰胺类药物(青霉素G、氧西林、头孢唑肟、头孢布烯、头孢西丁和头孢克洛)的最低抑菌浓度(MIC)。在确定为 SDSE 的 85 个分离株中,青霉素 G、氧西林、头孢唑肟、头孢布烯、头孢西丁和头孢克洛的 MIC 范围分别为 0.007-0.06、0.03-0.12、0.015-0.06、0.25-2、0.12-2 和 0.06-0.5 μg/mL。没有一个临床分离株对青霉素 G 不敏感,这表明所有 85 个 SDSE 临床分离株都对β-内酰胺类药物敏感。我们的研究结果表明,日本几个县的几乎所有 SDSE 临床分离株对β-内酰胺类药物仍然敏感。尽管如此,仍有必要对日本 SDSE 临床分离株的药敏性进行持续、仔细的监测。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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