24-h Glucose profile of patients with gestational diabetes mellitus and comparison with pregnant women with normoglycemia

IF 0.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM International Journal of Diabetes in Developing Countries Pub Date : 2024-01-29 DOI:10.1007/s13410-024-01311-x

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引用次数: 0

Abstract

Objective

To study the 24-h glucose profile of patients with mild GDM using the commercially available Abbot Libre continuous glucose monitoring system (CGMS) and compare them with pregnant women with normoglycemia (gestational age comparable).

Methods

A case control study conducted between 2019-2020 followed eligible pregnant women diagnosed with GDM according to Diabetes in Pregnancy Study Group India criteria, after the placement of a CGMS.

Results

Twenty-one GDM patients whose mean age was 27.1 ± 3.3 years with gestational age 28 weeks (24–32) and thirty pregnant women with normoglycemia whose mean age was 25.7 ± 4.2 years and gestational age 26 weeks (23–34) were enrolled in the study. Fasting, pre-breakfast, 2 h post lunch, day time and lowest nocturnal glucose were significantly higher in the GDM group than in controls. Glycemic variability indices like standard deviation of blood glucose, J index, and mean amplitude of glycemic excursions were also significantly higher in GDM patients. GDM patients spent more time above >140 mg/dl than controls.

Conclusion

GDM patients, who have mild hyperglycemia but not overt diabetes, also have an abnormal 24 h glucose profile as compared to normal pregnancy.

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妊娠糖尿病患者的 24 小时血糖谱以及与血糖正常孕妇的比较

摘要目的使用市售的 Abbot Libre 连续血糖监测系统（CGMS）研究轻度 GDM 患者的 24 小时血糖情况，并将其与血糖正常（孕龄相当）的孕妇进行比较。方法 2019-2020 年间进行的一项病例对照研究，对根据妊娠期糖尿病研究小组印度标准诊断为 GDM 的合格孕妇在安装 CGMS 后的情况进行了跟踪。结果 21 名 GDM 患者（平均年龄为 27.1±3.3 岁，孕周为 28 周（24-32））和 30 名血糖正常的孕妇（平均年龄为 25.7±4.2 岁，孕周为 26 周（23-34））被纳入研究。GDM 组的空腹血糖、早餐前血糖、午餐后 2 小时血糖、日间血糖和夜间最低血糖均明显高于对照组。GDM 患者的血糖变异性指数，如血糖标准偏差、J 指数和血糖偏移的平均振幅也明显高于对照组。与对照组相比，GDM 患者血糖超过 140 mg/dl 的时间更长。结论 GDM 患者有轻度高血糖，但不是明显的糖尿病，与正常妊娠相比，他们的 24 小时血糖谱也不正常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Diabetes in Developing Countries ENDOCRINOLOGY & METABOLISM-

CiteScore

1.60

自引率

0.00%

发文量

109

审稿时长

6 months

期刊介绍： International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.