{"title":"Natural Alkaloids and Mechanisms for Anti-cancer Action: A Review","authors":"Prem Mishra, Niranjan Kaushik, Rakhi Mishra, Sameeksha Koul, Sakshi Sagar","doi":"10.2174/0115734072276134231130170407","DOIUrl":null,"url":null,"abstract":"\n\nCancer is a global public health issue. Cancer therapy has been hampered by the issue\nof multidrug resistance, which is one of the leading causes of death worldwide. As a result, the\nuse of natural derived drugs for cancer prevention and therapy has been researched and developed\nfor decades. Alkaloids are plant-derived secondary metabolites that have antiproliferative and\nanticancer effects on several forms of cancer. Camptothecin and vinblastine, two anticancer medicines\nderived from alkaloids, have been adequately developed in the past. Alkaloids, a drug lead\ncompounds, derived from natural products, have the advantage of being used by the host, making\nthem suitable for further exploitation. The current review looks at the anticancer potential of numerous\nnaturally occurring alkaloids, as well as the mechanism behind their anticancer effect.\n","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Bioactive Compounds","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115734072276134231130170407","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer is a global public health issue. Cancer therapy has been hampered by the issue
of multidrug resistance, which is one of the leading causes of death worldwide. As a result, the
use of natural derived drugs for cancer prevention and therapy has been researched and developed
for decades. Alkaloids are plant-derived secondary metabolites that have antiproliferative and
anticancer effects on several forms of cancer. Camptothecin and vinblastine, two anticancer medicines
derived from alkaloids, have been adequately developed in the past. Alkaloids, a drug lead
compounds, derived from natural products, have the advantage of being used by the host, making
them suitable for further exploitation. The current review looks at the anticancer potential of numerous
naturally occurring alkaloids, as well as the mechanism behind their anticancer effect.
Current Bioactive CompoundsPharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍：
The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
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