The Causal Associations between Adipokines and Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-18 DOI:10.3233/adr-230110

Xiaoying Cai, Yaqing Wang, Ying Li, Zhanxin Du, Zhongxing Wang

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Abstract

Background: Observational studies have indicated the association of alteration of adipokines with Alzheimer’s disease (AD). However, it remains unclear whether the associations are causal. Objective: To determine the causal associations between adipokines and AD. Methods: A Mendelian randomization (MR) method was applied to investigate the causal relationships of adipokines, including adiponectin and resistin, with risk of AD. Genetic proxies from genome-wide association studies (GWAS) of adiponectin and resistin were selected as instrumental variables. GWAS summary statistics for AD were extracted as outcome. Results: In this study, we found evidence of the causal effects of adiponectin on AD (OR: 0.850, 95% CI: 0.731-0.990, p = 0.037). However, no relationship between resistin and AD (OR: 0.936, 95% CI: 0.851-1.029, p = 0.171) was detected. In the reverse causation analysis, null associations of AD were found for adiponectin and resistin (all p > 0.05). Conclusions: This study provides evidence of causality between adiponectin and risk of AD. However, no genetic susceptibility of resistin was discovered for AD.

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脂肪因子与阿尔茨海默病之间的因果关系：双样本孟德尔随机研究

背景：观察性研究表明，脂肪因子的改变与阿尔茨海默病（AD）有关。然而，这种关联是否是因果关系仍不清楚。研究目的确定脂肪因子与阿尔茨海默病之间的因果关系。方法：采用孟德尔随机方法（MRM）进行研究：采用孟德尔随机化（MR）方法研究脂肪因子（包括脂肪连接蛋白和抵抗素）与 AD 风险的因果关系。研究人员从脂肪连素和抵抗素的全基因组关联研究（GWAS）中选取了基因替代物作为工具变量。提取有关注意力缺失症的全基因组关联研究摘要统计数据作为研究结果。研究结果在这项研究中，我们发现了脂肪连接蛋白对注意力缺失症具有因果效应的证据（OR：0.850，95% CI：0.731-0.990，p = 0.037）。然而，没有检测到抵抗素与 AD 之间的关系（OR：0.936，95% CI：0.851-1.029，p = 0.171）。在反向因果关系分析中，发现脂肪连素和抵抗素与注意力缺失症的关系为空（所有 p > 0.05）。结论本研究提供了脂肪连接蛋白与 AD 风险之间因果关系的证据。然而，研究并未发现抗抑素对艾滋病有遗传易感性。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.