The effect of Melissa officinalis on diet-induced hyperlipidemia, hypercholesterolemia, oxidative stress and inflammation

Pub Date : 2024-01-18 DOI:10.12681/jhvms.30235

Ö. Hazman, ME Göçeri, I. Fıçıcı, B. Demirer, L. Aksoy

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Abstract

The Lamiaceae family is an essential medicinal plant family. Melissa officinalis L. is a well-known medicinal plant of Lamiaceae. It was aimed to investigate the effects of Melissa officinalis infusion given to rats with hyperlipidemia and hypercholesterolemia in this study. It is seen that the high-fat diet (HFD) group causes weight gain from the third week. VLDL, LDL, HDL and cholesterol levels were found statistically significant differences (p˂0.05), fed a cholesterol-enriched high-fat diet group (HFD) compared to the control. It is seen that the cholesterol level of the high-fat diet+Melissa officinalis infusion (HFD+MOI) group was statistically significantly (p˂0.05). lower than the HFD group. In addition, the group in which Melissa officinalis was applied had positive effects on the antioxidant system and reduced the total oxidant system. The fact that the IFN-γ level of the HFD group was higher than the control indicates that the diet may have an inflammatory effect. As a result, HFD application with cholesterol caused hyperlipidemia and hypercholesterolemia in rats. The cholesterol-lowering effect of Melissa officinalis is observed. Remarkably, Melissa officinalis did not alter serum calcium levels while lowering cholesterol. In addition, it can said that HFD has a strengthening effect on the antioxidant system on oxidative stress.

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香蜂草对饮食诱导的高脂血症、高胆固醇血症、氧化应激和炎症的影响

唇形科是一个重要的药用植物科。Melissa officinalis L. 是一种著名的唇形科药用植物。本研究旨在探讨给高脂血症和高胆固醇血症大鼠注射香蜂草的效果。结果表明，高脂饮食（HFD）组从第三周开始体重增加。与对照组相比，喂食富含胆固醇的高脂饮食组（HFD）的 VLDL、LDL、HDL 和胆固醇水平差异有统计学意义（p˂0.05）。可以看出，高脂饮食+香紫苏注射液（HFD+MOI）组的胆固醇水平低于高脂饮食组，差异有统计学意义（p˂0.05）。此外，应用黄花苷的组对抗氧化系统有积极影响，并降低了总氧化系统。高纤维食物组的 IFN-γ 水平高于对照组，这表明饮食可能具有炎症效应。因此，添加胆固醇的高密度脂蛋白胆固醇膳食会导致大鼠高脂血症和高胆固醇血症。可以观察到香蜂草有降低胆固醇的作用。值得注意的是，香蜂草在降低胆固醇的同时不会改变血清钙水平。此外，可以说高纤维食物对氧化应激的抗氧化系统有强化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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