{"title":"Vitamin C in dermatology and cosmetology: a review","authors":"S. Mohan, Neelu Singh, Lalit Mohan","doi":"10.18203/issn.2455-4529.intjresdermatol20240023","DOIUrl":null,"url":null,"abstract":"Vitamin C is a very powerful water-soluble antioxidant with various potential benefits for patients with skin diseases. The chemically active form of vitamin C is L-ascorbic acid (LAA) and thus is used extensively in medical practices. Due to an active transport mechanism, the absorption of vitamin C in the gut is limited, thereby reducing the amount of drug absorbed orally despite a high dosage, which in turn reduces the bioavailability of vitamin C in the skin. Therefore, topical use of vitamin C is usually preferred in dermatology practice. The function of vitamin C is mostly linked to its electron-donating property. Several processes such as reduction of iron in the gastrointestinal tract, synthesis of carnitine, gene transcription, protection against reactive oxygen species (ROS), demethylation of DNA, Hydroxylation of transcription factors, tRNA, and ribosomal proteins, collagen, and hormonal synthesis are carried out due to the active participation of vitamin C in the body. Scurvy usually occurs due to inadequate consumption of vitamin C through a regular diet or inability to absorb the vitamin C in the body. 90% of ascorbic acid comes from fresh fruits and vegetable consumption, failure of which can lead to scurvy.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":" 8","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20240023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Vitamin C is a very powerful water-soluble antioxidant with various potential benefits for patients with skin diseases. The chemically active form of vitamin C is L-ascorbic acid (LAA) and thus is used extensively in medical practices. Due to an active transport mechanism, the absorption of vitamin C in the gut is limited, thereby reducing the amount of drug absorbed orally despite a high dosage, which in turn reduces the bioavailability of vitamin C in the skin. Therefore, topical use of vitamin C is usually preferred in dermatology practice. The function of vitamin C is mostly linked to its electron-donating property. Several processes such as reduction of iron in the gastrointestinal tract, synthesis of carnitine, gene transcription, protection against reactive oxygen species (ROS), demethylation of DNA, Hydroxylation of transcription factors, tRNA, and ribosomal proteins, collagen, and hormonal synthesis are carried out due to the active participation of vitamin C in the body. Scurvy usually occurs due to inadequate consumption of vitamin C through a regular diet or inability to absorb the vitamin C in the body. 90% of ascorbic acid comes from fresh fruits and vegetable consumption, failure of which can lead to scurvy.
维生素 C 是一种非常强效的水溶性抗氧化剂,对皮肤病患者有各种潜在的益处。维生素 C 的化学活性形式是左旋抗坏血酸(LAA),因此在医疗实践中被广泛使用。由于活性转运机制,维生素 C 在肠道中的吸收受到限制,因此尽管用量很大,口服吸收的药量也会减少,这反过来又降低了维生素 C 在皮肤中的生物利用度。因此,在皮肤病治疗中,通常首选局部使用维生素 C。维生素 C 的功能主要与其电子负载特性有关。由于维生素 C 在体内的积极参与,一些过程得以进行,如还原胃肠道中的铁、合成肉碱、基因转录、抵御活性氧(ROS)、DNA 去甲基化、转录因子、tRNA 和核糖体蛋白的羟基化、胶原蛋白和激素合成。坏血病的发生通常是由于通过正常饮食摄入的维生素 C 不足或体内无法吸收维生素 C。90%的抗坏血酸来自于新鲜水果和蔬菜的摄入,不摄入新鲜水果和蔬菜会导致坏血病。