Bioengineering: a promising approach for standardization and automation of assisted reproductive technology

Abstract

Assisted reproductive technology (ART) is a commonly used treatment for infertile couples. However, the suboptimal success rate of ART highlights the urgent need for optimization. One promising strategy to significantly improve ART outcomes is to standardize and automate all steps involved, ranging from high-quality gamete selection to in vitro fertilization, embryo culture, embryo examination, and selection as well as gamete and embryo cryopreservation. Cutting-edge technologies, such as microfluidics and artificial intelligence (AI), have been developed for this purpose and have demonstrated remarkable potential in this area. Microfluidic systems have the potential to integrate ART steps into a miniaturized and automated device, which can minimize human error, save time and costs, enhance reproducibility and consistency, and improve accuracy. Additionally, AI is playing an increasingly important role in automating key aspects of ART. Leveraging its powerful abilities in rapid, accurate, and intelligent analysis of large biomedical datasets, AI assists doctors and embryologists in making more informed and effective decisions. In summary, these bioengineering technologies have the potential to revolutionize ART, making it faster, more efficient, and ultimately more effective for couples seeking to conceive. This article provides a comprehensive overview of how microfluidics and AI are being applied in ART to advance the field and benefit patients.