Production of interleukin-2 and expression of tac antigen in Hodgkin disease.

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

N N Joshi, R Mukhopadhyay, S H Advani, S G Gangal

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Abstract

Phytohemagglutinin (PHA)- induced Interleukin-2 (IL-2) production by peripheral blood mononuclear cells was studied in 28 untreated patients with Hodgkin Disease (HD). A group of 28 patients were also investigated for the expression of Tac antigen in the resting stage of lymphocytes and after activation with PHA and mixed leukocyte culture (using anti-Tac monoclonal antibody). The blastogenic response to PHA and IL-2 production by lymphocytes of HD patients was significantly lower than that of normal lymphocytes. Production of IL-2 appeared to be severely affected in 14 of 28 HD patients who also showed PHA response less than the normal range. The Tac antigen expression was found to be lower in PHA-stimulated but not alloantigen-stimulated lymphocytes from the HD patients. No correlation was observed between the levels of IL-2 production, Tac antigen expression, and blastogenic response to PHA or allogeneic cells and the stage of disease when tested in the same patients.

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霍奇金病中白细胞介素-2的产生和tac抗原的表达。

在28例未经治疗的霍奇金病(HD)患者中研究了植物血凝素(PHA)诱导外周血单个核细胞产生白细胞介素-2 (IL-2)。同时观察28例患者静息期淋巴细胞、PHA活化及混合白细胞培养(抗Tac单克隆抗体)后Tac抗原的表达情况。HD患者淋巴细胞对PHA和IL-2产生的成母反应明显低于正常淋巴细胞。28例HD患者中有14例IL-2的产生受到严重影响，这些患者的PHA反应也低于正常范围。在HD患者的pha刺激淋巴细胞中Tac抗原表达较低，而同种异体抗原刺激淋巴细胞中Tac抗原表达较低。在同一患者中检测时，未观察到IL-2产生水平、Tac抗原表达水平以及对PHA或同种异体细胞的成母反应与疾病阶段之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc

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