Headaches in Children After Transcatheter Device Closure of Atrial Septal Defects: A Single-Centre Experience

Joshua D. Griesman MBBCh, MSc, Audrey C. Marshall MD, MPH
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Abstract

Background

Transcatheter device closure (TDC) is the most common treatment for isolated atrial septal defects in children. In the adult population, the incidence of new-onset migraine headache after TDC is well recognized and is estimated at 15%. New-onset headache after paediatric TDC has not been well described. We reviewed our centre’s experience to estimate the rate of headache complaints among paediatric patients after TDC.

Methods

We performed a single-centre, retrospective review of all children who underwent TDC between January 1, 2018, and December 31, 2021. For the included patients, we comprehensively reviewed the electronic medical record to identify patients reported to experience post-TDC headache.

Results

A total of 165 consecutive patients underwent TDC during the study period. Of these, 134 met inclusion criteria, and 20 patients (15%) had headache documented in the electronic medical record. Of 20 patients, 4 (20%) had headaches that led to further investigation or changed postprocedural medical management. Two patients had brain magnetic resonance imaging to investigate headaches; both studies were interpreted as nonpathologic. One patient required emergency department management for status migrainosus. A second, with a prior history of migraine, required admission for migraine exacerbation. In addition to those needing symptomatic management, 3 patients had a change in their antiplatelet regimen from aspirin to clopidogrel.

Conclusions

Our study suggests a minimal estimate of 15% as the incidence of headache in children who undergo TDC. This estimate can inform counselling before TDC. Determination of the true incidence will require focused prospective data collection.

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儿童经导管装置关闭房间隔缺损后的头痛:单中心经验
背景导管装置闭合术(TDC)是治疗儿童孤立性房间隔缺损最常见的方法。在成人中,TDC 后新发偏头痛的发生率已得到公认,估计为 15%。儿科 TDC 术后新发头痛的情况尚未得到很好的描述。我们回顾了本中心的经验,以估计儿童患者在 TDC 后的头痛投诉率。方法我们对 2018 年 1 月 1 日至 2021 年 12 月 31 日期间接受 TDC 的所有儿童进行了单中心回顾性审查。对于纳入的患者,我们全面审查了电子病历,以确定据报告出现 TDC 后头痛的患者。其中 134 例符合纳入标准,20 例患者(15%)在电子病历中记录有头痛症状。在 20 名患者中,有 4 名患者(20%)的头痛导致了进一步的检查或改变了术后的医疗管理。两名患者接受了脑磁共振成像检查以确定是否患有头痛;这两项检查均被解释为非病理性头痛。一名患者因状态性偏头痛需要急诊治疗。另一名患者之前有偏头痛病史,因偏头痛加重而需要入院治疗。除了需要对症治疗外,3 名患者的抗血小板疗法也从阿司匹林改为氯吡格雷。我们的研究表明,接受 TDC 的儿童头痛发生率最低估计为 15%,这一估计值可为 TDC 前的咨询提供参考。要确定真正的发病率,需要有针对性地收集前瞻性数据。
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