Study of the factors related to air-bone gap in enlarged vestibular aqueduct.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI:10.1080/00016489.2024.2308014

Rong Wang, Bo-Xiang Zhuang, Weiwei Guo, Jianan Li, Chang Lin, Shiming Yang

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Abstract

Background: Over half of patients with enlarged vestibular aqueducts (EVA) will have an air-bonr gap (ABG), however, current research on audiology has focused on the influencing factors of air-conducted.

Objective: To retrospectively analyse the influencing factors and clinical manifestations of the bone-conduction threshold and ABG in patients with EVA.

Materials and methods: We included 286 patients with EVA; among them, 126 had full SLC26A4 gene sequence results. We performed a descriptive analysis of the bone-conduction threshold and explored the effect of age. Finally, we analyzed the relationship of ABG and SLC26A4 genes with the degree of vestibular aqueduct (VA) enlargement.

Results: Among 555 ears, 312 (57.8%) ears had ABG; approximately 94% of the patients' bone-conduction hearing is almost completely lost at frequencies of 2 and 4 kHz. There was no linear correlation between age and bone-conduction threshold (p > 0.05). ABG did not significantly differ according to the degree of VA enlargement and number of SLC26A4 allele mutations (p > 0.05).

Conclusions and significance: Among patients with EVA, ABG is mainly produced at low frequencies and is not significantly correlated with age, size of the VA opening or SLC26A4 genes, which could be attributed to the biomechanical effects.

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前庭导水管扩大与气骨间隙相关因素的研究

背景：半数以上的前庭导水管扩大（EVA）患者会出现气-骨间隙（ABG），然而，目前的听力学研究主要集中在气导阈的影响因素上：回顾性分析 EVA 患者骨导阈和 ABG 的影响因素和临床表现：我们纳入了286例EVA患者，其中126例有完整的SLC26A4基因序列结果。我们对骨传导阈值进行了描述性分析，并探讨了年龄的影响。最后，我们分析了 ABG 和 SLC26A4 基因与前庭导水管（VA）扩大程度的关系：在 555 耳中，312 耳（57.8%）有 ABG；约 94% 的患者在 2 和 4 kHz 频率下几乎完全丧失骨传导听力。年龄与骨导阈值之间没有线性关系（P > 0.05）。ABG与VA扩大程度和SLC26A4等位基因突变数量无明显差异（P > 0.05）：在EVA患者中，ABG主要以低频产生，与年龄、VA开口大小或SLC26A4基因无明显相关性，这可能归因于生物力学效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.