Head-to-head comparison of ¹⁸F-FDG PET/CT and ¹⁸F-FDG PET/MRI for lymph node metastasis staging in non-small cell lung cancer: a meta-analysis.

IF 1.4 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Diagnostic and interventional radiology Pub Date : 2024-03-06 Epub Date: 2024-01-31 DOI:10.4274/dir.2023.232280

Min Zhang, Zhikang Liu, Yuhang Yuan, Wenwen Yang, Xiong Cao, Minjie Ma, Biao Han

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Abstract

Purpose: The current meta-analysis aimed to compare the diagnostic performance of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) with ¹⁸F-FDG PET/magnetic resonance imaging (MRI) in non-small cell lung cancer (NSCLC) lymph node metastasis staging.

Methods: We searched the PubMed, Web of Science, and Embase databases for relevant articles between November 1992 and September 2022. Studies evaluating the head-to-head comparison of ¹⁸F-FDG PET/CT and ¹⁸F-FDG PET/MRI for lymph node metastasis in patients with NSCLC were included. The quality of each study was assessed using the Quality Assessment of Diagnostic Performance Studies-2 tool.

Results: The analysis includes six studies with a total of 434 patients. The pooled sensitivity of ¹⁸F-FDG PET/CT and ¹⁸F-FDG PET/MRI was 0.78 [95% confidence interval (CI): 0.59-0.90] and 0.84 (95% CI: 0.68-0.93), and the pooled specificity was 0.87 (95% CI: 0.72-0.94) and 0.87 (95% CI: 0.80-0.92), respectively. The accuracy of ¹⁸F-FDG PET/CT and ¹⁸F-FDG PET/MRI was 0.81 (95% CI: 0.71-0.90) and 0.84 (95% CI: 0.75-0.92), respectively. When the pre-test probability was set at 50%, the post-test probability for ¹⁸F-FDG PET/CT could increase to 85%, and the post-test probability for ¹⁸F-FDG PET/MRI could increase to 87%.

Conclusion: ¹⁸F-FDG PET/CT and ¹⁸F-FDG PET/MRI have similar diagnostic performance in detecting lymph node metastasis in NSCLC. However, the results of this study were from a small sample study, and further studies with larger sample sizes are needed.

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18F-FDG PET/CT 和 18F-FDG PET/MRI 对非小细胞肺癌淋巴结转移分期的正面比较：一项荟萃分析。

目的：本荟萃分析旨在比较18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）与18F-FDG PET/磁共振成像（MRI）在非小细胞肺癌（NSCLC）淋巴结转移分期中的诊断效果：我们在 PubMed、Web of Science 和 Embase 数据库中检索了 1992 年 11 月至 2022 年 9 月期间的相关文章。纳入的研究评估了 18F-FDG PET/CT 和 18F-FDG PET/MRI 对 NSCLC 患者淋巴结转移的头对头比较。采用诊断性能研究质量评估-2工具对每项研究的质量进行评估：结果：分析包括六项研究，共涉及 434 名患者。18F-FDG PET/CT 和 18F-FDG PET/MRI 的集合敏感性分别为 0.78 [95% 置信区间 (CI)：0.59-0.90] 和 0.84 (95% CI：0.68-0.93)，集合特异性分别为 0.87 (95% CI：0.72-0.94) 和 0.87 (95% CI：0.80-0.92)。18F-FDG PET/CT 和 18F-FDG PET/MRI 的准确性分别为 0.81（95% CI：0.71-0.90）和 0.84（95% CI：0.75-0.92）。结论：18F-FDG PET/CT 和 18F-FDG PET/MRI 在检测 NSCLC 淋巴结转移方面具有相似的诊断性能。结论：18F-FDG PET/CT和18F-FDG PET/MRI在检测NSCLC淋巴结转移方面具有相似的诊断效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diagnostic and interventional radiology Medicine-Radiology, Nuclear Medicine and Imaging

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期刊介绍： Diagnostic and Interventional Radiology (Diagn Interv Radiol) is the open access, online-only official publication of Turkish Society of Radiology. It is published bimonthly and the journal’s publication language is English. The journal is a medium for original articles, reviews, pictorial essays, technical notes related to all fields of diagnostic and interventional radiology.