Relationship between visual acuity and OCT angiography parameters in diabetic retinopathy eyes after treatment.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY European Journal of Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-01-30 DOI:10.1177/11206721241228010

Selena Wei-Zhang, Kai He, Wei Zhou, Jinguo Yu, Jing Zhao, Tiangeng He, Song Chen, Parhat Kaysar, Zhiyong Sun, Dagong Jia, Yun Zhu, Hua Yan

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Abstract

Purpose: To assess the relationship between visual acuity and OCT angiography parameters in diabetic retinopathy eyes after treatment, and to analyze the relative factors in PDR eyes.

Methods: A total of 89 eyes, including 42 eyes with non-PDR (NPDR), and 47 eyes after vitrectomy with PDR were included and underwent OCTA. All images were processed by Python or FIJI. Multivariable linear regression models were used to analyze the associations between postoperative BCVA and OCTA parameters in PDR patients.

Results: Postoperative OCTA parameters including deep capillary plexus (DCP) parafoveal and perifoveal vessel density (VD), DCP parafoveal and perifoveal vessel length density (VLD), DCP fractal dimension (FD), choriocapillaris plexus (CCP) VD, CCP VLD, were significantly lower in the PDR group than in the NPDR group. In the superficial capillary plexus (SCP), we found a negative correlation between the postoperative BCVA and VD (parafovea: β coefficient = -0.351, p = 0.023; perifovea: β coefficient = -0.338, p = 0.036). Perifoveal VLD (β coefficient = -0.343, p = 0.031) and FD (β coefficient = -0.375, p = 0.016) of the SCP were also negatively correlated with postoperative BCVA. Regarding the DCP, perifoveal VD (β coefficient = -0.396, p = 0.008), perifoveal VLD (β coefficient = -0.334, p = 0.025), vessel tortuosity (VT) (β coefficient = -0.369, p = 0.015) were negatively correlated with postoperative BCVA. In CCP, VLD (β coefficient = -0.373, p = 0.023) and number of flow voids (β coefficient = -0.334, p = 0.036) exhibited a negative association with postoperative BCVA.

Conclusions: Postoperative BCVA of PDR patients was related to OCTA parameters of the SCP (parafoveal and perifoveal VD, perifoveal VLD and FD), DCP (perifoveal VD, VLD, and VT) and CCP (VLD and number of flow voids).

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糖尿病视网膜病变患者治疗后视力与 OCT 血管造影参数之间的关系。

目的：评估糖尿病视网膜病变眼治疗后视力与OCT血管造影参数之间的关系，并分析PDR眼的相关因素：共纳入 89 只眼睛，包括 42 只非 PDR（NPDR）眼睛和 47 只接受玻璃体切除术后的 PDR 眼睛，并对其进行了 OCTA 检查。所有图像均由 Python 或 FIJI 处理。采用多变量线性回归模型分析了PDR患者术后BCVA和OCTA参数之间的关联：结果：PDR组的术后OCTA参数，包括深毛细血管丛（DCP）眼窝旁和眼窝周围血管密度（VD）、DCP眼窝旁和眼窝周围血管长度密度（VLD）、DCP分形维度（FD）、绒毛膜丛（CCP）VD、CCP VLD，均显著低于NPDR组。在毛细血管浅丛（SCP），我们发现术后 BCVA 与 VD 之间呈负相关（眼窝旁：β 系数 = -0.351，p =0.023；眼窝周围：β 系数 = -0.338，p =0.036）。SCP的眼周VLD（β系数=-0.343，p=0.031）和FD（β系数=-0.375，p=0.016）也与术后BCVA呈负相关。在 DCP 中，眼窝周围 VD（β 系数 = -0.396，p = 0.008）、眼窝周围 VLD（β 系数 = -0.334，p = 0.025）、血管迂曲度（VT）（β 系数 = -0.369，p = 0.015）与术后 BCVA 呈负相关。在 CCP 中，VLD（β 系数 = -0.373，p =0.023）和血流空洞数（β 系数 = -0.334，p =0.036）与术后 BCVA 呈负相关：结论：PDR 患者术后 BCVA 与 SCP（视网膜旁和视网膜周围 VD、视网膜周围 VLD 和 FD）、DCP（视网膜周围 VD、VLD 和 VT）和 CCP（VLD 和血流空洞数）的 OCTA 参数有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Ophthalmology 医学-眼科学

CiteScore

3.60

自引率

0.00%

发文量

372

审稿时长

3-8 weeks

期刊介绍： The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.