Association between systemic sclerosis and venous thromboembolism, pulmonary embolism, and deep vein thrombosis: a meta-analysis.

IF 0.9 4区医学 Q4 RHEUMATOLOGY Zeitschrift fur Rheumatologie Pub Date : 2024-12-01 Epub Date: 2024-01-31 DOI:10.1007/s00393-024-01481-3

Young Ho Lee, Gwan Gyu Song

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Abstract

Objective: This study aimed to analyze the published data pertaining to the correlation between venous thromboembolism (VTE) and systemic sclerosis (SSc).

Methods: We conducted manual searches and explored MEDLINE, EMBASE, and Cochrane databases to review papers reporting the risk of VTE in patients with SSc. A meta-analysis was performed exploring the relative risks (RRs) of deep vein thrombosis (DVT), pulmonary embolism (PE), and VTE in these individuals.

Results: Six trials that included 41,105 patients with SSc were eligible for inclusion. A meta-analysis of the six included studies revealed a statistically significant correlation (RR 2.372, 95% confidence interval [CI] = 1.608-3.500, p < 0.001) between the risk of VTE and SSc. Regional subgroup study revealed a strong correlation between SSc and VTE risk in Americans, Europeans, and Asians. Additionally, a significant correlation between SSc and PE risk was observed (RR 3.154, 95% CI = 1.320-7.539, p = 0.010). Finally, the meta-analysis revealed a substantial correlation (RR 5.190, 95% CI = 1.513-17.01, p = 0.009) between the risk of DVT and SSc.

Conclusion: This meta-analysis showed that SSc is linked to an increased risk of DVT, PE, and VTE. This finding underscores the importance of close monitoring for the emergence of these conditions in patients with SSc.

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系统性硬化症与静脉血栓栓塞、肺栓塞和深静脉血栓形成之间的关系：一项荟萃分析。

研究目的本研究旨在分析已发表的有关静脉血栓栓塞症（VTE）与系统性硬化症（SSc）之间相关性的数据：我们进行了人工检索，并在 MEDLINE、EMBASE 和 Cochrane 数据库中查阅了报告 SSc 患者 VTE 风险的论文。我们进行了一项荟萃分析，探讨了这些患者发生深静脉血栓（DVT）、肺栓塞（PE）和 VTE 的相对风险（RRs）：六项试验共纳入了41105名SSc患者，符合纳入条件。对纳入的六项研究进行的荟萃分析表明，这六项研究之间存在显著的统计学相关性（RR 2.372，95% 置信区间 [CI] = 1.608-3.500，P 结论：荟萃分析表明，SSc 患者的血栓形成（DVT）与肺栓塞（PE）和 VTE 之间存在显著的统计学相关性：这项荟萃分析表明，SSc 与深静脉血栓、PE 和 VTE 风险增加有关。这一发现强调了密切监测 SSc 患者出现这些情况的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift fur Rheumatologie 医学-风湿病学

CiteScore

2.20

自引率

20.00%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Die Zeitschrift für Rheumatologie ist ein international angesehenes Publikationsorgan und dient der Fortbildung von niedergelassenen und in der Klinik tätigen Rheumatologen. Die Zeitschrift widmet sich allen Aspekten der klinischen Rheumatologie, der Therapie rheumatischer Erkrankungen sowie der rheumatologischen Grundlagenforschung. Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht dabei gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit – der Leser erhält konkrete Handlungsempfehlungen. Frei eingereichte Originalien ermöglichen die Präsentation wichtiger klinischer Studien und dienen dem wissenschaftlichen Austausch.