Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats
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引用次数: 0
Abstract—
Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxia-inducible factor 1 (HIF1α) in the hippocampus of adult and aging rats, whose mothers were exposed to severe damaging hypoxia during days 14-16 of pregnancy. Furthermore, we assessed the relative abundance of mRNA for HIF1-regulated genes (hk1, ldha, mct4, pdk1) using quantitative real-time PCR in adult rats. Our findings indicate that prenatal hypoxia induces a sustained increase in HIF1α expression in the hippocampus. Additionally, we observed an accompanying elevation in the mRNA levels of the investigated HIF1-regulated genes. These results suggest that prenatal hypoxia exerts a lasting impact on hippocampal metabolism. Consequently, these metabolic disruptions may persist throughout life.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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