{"title":"T-Cell Aspects of Some Neurological Diseases","authors":"","doi":"10.1134/s1819712423040153","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract</strong>—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are the most frequent. On the contrary, amyotrophic lateral sclerosis is most often considered as a disease, whose development is practically not associated with changes in the function of the immune system. This review summarizes the latest data on changes in the T-lymphocyte subpopulations and their function in the blood and cerebrospinal fluid in the aforementioned diseases. These data suggest that regulatory T cells and NKT cells may play an important role in the development of the discussed pathologies. We stress the necessity of accumulation and analysis of data on T-cell subpopulations, as well as the sequence of T-cell receptors, HLA, and CD1 in patients for the development of approaches to the diagnosis and possible therapy of these diseases.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s1819712423040153","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are the most frequent. On the contrary, amyotrophic lateral sclerosis is most often considered as a disease, whose development is practically not associated with changes in the function of the immune system. This review summarizes the latest data on changes in the T-lymphocyte subpopulations and their function in the blood and cerebrospinal fluid in the aforementioned diseases. These data suggest that regulatory T cells and NKT cells may play an important role in the development of the discussed pathologies. We stress the necessity of accumulation and analysis of data on T-cell subpopulations, as well as the sequence of T-cell receptors, HLA, and CD1 in patients for the development of approaches to the diagnosis and possible therapy of these diseases.
摘要--多发性神经病是免疫介导的一组异质性疾病，其中以格林-巴利综合征和慢性炎症性脱髓鞘多发性神经病最为常见。相反，肌萎缩性脊髓侧索硬化症通常被认为是一种与免疫系统功能变化无关的疾病。本综述总结了有关上述疾病中血液和脑脊液中 T 淋巴细胞亚群及其功能变化的最新数据。这些数据表明，调节性 T 细胞和 NKT 细胞可能在上述病症的发展过程中扮演重要角色。我们强调有必要积累和分析患者体内 T 细胞亚群的数据以及 T 细胞受体、HLA 和 CD1 的序列，以开发诊断和治疗这些疾病的方法。
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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