Association Between Serum Uric Acid Levels and Neoatherosclerosis An Optical Coherence Tomography Study in Patients with In-Stent Restenosis

IF 1.2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS International heart journal Pub Date : 2024-01-31 DOI:10.1536/ihj.23-058

Ning Gu, Zhijiang Liu, Zhenglong Wang, Changyin Shen, Wei Zhang, Hongqin Tian, Xi Wang, Shuangya Yang, Ranzun Zhao, Bei Shi

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Abstract

Neoatherosclerosis is a major cause of stent failure after percutaneous coronary intervention. Metabolism such as hyperuricemia is associated with in-stent restenosis (ISR). However, the association between serum uric acid (sUA) levels and in-stent neoatherosclerosis (ISNA) has never been validated.

A total of 216 patients with 220 ISR lesions who had undergone optical coherence tomography (OCT) of culprit stents were included in this study. According to their sUA levels, eligible patients were divided into two groups [normal-sUA group: sUA < 7 mg/dL, n = 126, and high-sUA group: sUA ≥ 7 mg/dL, n = 90]. OCT findings were analyzed and compared between the normal- and high-sUA groups.

The incidence of ISNA (63.0% versus 43.0%, P = 0.004) was significantly higher in the high-sUA group than in the normal-sUA group. Lipid plaques (66.3% versus 43.0%, P < 0.001) and thin-cap fibroatheroma (38.0% versus 18.0%, P = 0.001) were observed more frequently in the restenotic tissue structure in patients in the high-sUA group than in those in the normal-sUA group. Meanwhile, univariate (OR: 1.208, 95% CI: 1.037-1.407; P = 0.015) and multivariate (OR: 1.254, 95% CI: 1.048-1.501; P = 0.013) logistic regression analyses indicated that sUA levels were an independent risk factor for ISNA after adjusting for relevant risk factors.

The high-sUA levels were an independent risk factor for the occurrence of neoatherosclerosis in patients with ISR via OCT.

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支架内再狭窄患者血清尿酸水平与新动脉硬化之间的关系一项光学相干断层扫描研究

新动脉硬化是经皮冠状动脉介入治疗后支架失效的主要原因。高尿酸血症等新陈代谢与支架内再狭窄（ISR）有关。然而，血清尿酸（sUA）水平与支架内新动脉粥样硬化（ISNA）之间的关系却从未得到过验证。本研究共纳入了216名患有220个ISR病变的患者，他们都接受了罪魁祸首支架的光学相干断层扫描（OCT）检查。根据患者的 sUA 水平，符合条件的患者被分为两组[正常-sUA 组：sUA < 7 mg/dL，n = 126；高-sUA 组：sUA ≥ 7 mg/dL，n = 90]。对正常UA组和高UA组的OCT结果进行了分析和比较。高UA组的ISNA发生率（63.0%对43.0%，P = 0.004）明显高于正常UA组。在高UA组患者的再狭窄组织结构中，脂质斑块（66.3%对43.0%，P <0.001）和薄帽纤维血管瘤（38.0%对18.0%，P = 0.001）的观察频率高于正常UA组。同时，单变量（OR：1.208，95% CI：1.037-1.407；P = 0.015）和多变量（OR：1.254，95% CI：1.048-1.501；P = 0.013）逻辑回归分析表明，在调整相关危险因素后，sUA水平是ISNA的独立危险因素。

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来源期刊

International heart journal 医学-心血管系统

CiteScore

2.50

自引率

6.70%

发文量

148

审稿时长

6-12 weeks

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