Effect of smoking on methylation and semen parameters

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES Environmental and Molecular Mutagenesis Pub Date : 2024-02-01 DOI:10.1002/em.22583
Nasim Naeimi, Homa Mohseni Kouchesfehani, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb
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Abstract

One type of epigenetic modification is genomic DNA methylation, which is induced by smoking, and both are associated with male infertility. In this study, the relationship between smoking and CHD5 gene methylation and semen parameters in infertile men was determined. After the MS-PCR of blood in 224 samples, 103 infertile patients (62 smokers and 41 non-smokers) and 121 fertile men, methylation level changes between groups and the effect of methylation and smoking on infertility and semen parameters in infertile men were determined. The results showed that there is a significant difference in the methylation status (MM, MU, UU) of the CHD5 gene between the patient and the control group, and this correlation also exists for the semen parameters (p < .001). The average semen parameters in smokers decreased significantly compared to non-smokers and sperm concentration was (32.21 ± 5.27 vs. 55.27 ± 3.38), respectively. MM methylation status was higher in smokers (22.5%) compared to non-smokers (14.6%). Smoking components affect the methylation pattern of CHD5 gene, and smokers had higher methylation levels and lower semen parameters than non-smokers, which can be biomarkers for evaluating semen quality and infertility risk factors. Understanding the epigenetic effects of smoking on male infertility can be very useful for predicting negative consequences of smoking and providing therapeutic solutions.

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吸烟对甲基化和精液参数的影响
其中一种表观遗传修饰是基因组 DNA 甲基化,而吸烟会诱导基因组 DNA 甲基化,这两种修饰都与男性不育有关。本研究测定了不育男性吸烟和 CHD5 基因甲基化与精液参数之间的关系。对 103 名不育患者(62 名吸烟者和 41 名非吸烟者)和 121 名已育男性的 224 份血液样本进行 MS-PCR 检测后,确定了各组间甲基化水平的变化以及甲基化和吸烟对不育男性不育症和精液参数的影响。结果显示,患者组和对照组之间 CHD5 基因的甲基化状态(MM、MU、UU)存在显著差异,这种相关性也存在于精液参数中(p
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来源期刊
CiteScore
5.40
自引率
10.70%
发文量
52
审稿时长
12-24 weeks
期刊介绍: Environmental and Molecular Mutagenesis publishes original research manuscripts, reviews and commentaries on topics related to six general areas, with an emphasis on subject matter most suited for the readership of EMM as outlined below. The journal is intended for investigators in fields such as molecular biology, biochemistry, microbiology, genetics and epigenetics, genomics and epigenomics, cancer research, neurobiology, heritable mutation, radiation biology, toxicology, and molecular & environmental epidemiology.
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