The Possible Protective Effect of Taurine on Bisphenol Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study.

Samah Kandeel, Marwa M Abd-Elsalam, Sherief Abd-Elsalam, Heba Hassan Elkaliny
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Abstract

Introduction: Bisphenol A (BPA) is a chemical compound that has been used in many industries, such as paints and dental sealants. Taurine is a semi-essential amino acid with antioxidant, anti-inflammatory, and anti-apoptotic actions.

Aim: This study aimed to evaluate the possible protective effect of taurine on BPA-induced structural changes in the cerebral cortex of rats using histological and immunohistochemical methods.

Methods: 35 Wistar rats (180-200 gm) were divided into control: 10 rats; Group I: 5 rats received corn oil (0.5 mL/day); Group II (Bisphenol low dose; BPAL): 5 rats received a low dose of BPA (25 mg/kg/three times/week); Group III (Bisphenol high dose; BPAH): 5 rats received a high dose of BPA (100 mg/kg/three times/week; Group IV: (BPAL + taurine): 5 rats received taurine 100 mg/kg/day and BPAL (25 mg/kg/three times/week); Group V: (BPAH + taurine): 5 rats received taurine 100 mg/kg/day and BPH (100 mg/kg/ three times/week).

Results: BPAL& BPAH groups showed significant dose-dependent histological changes of the neuropil, pyramidal, and neuroglial cells at H&E stained sections, significantly increased GFAP, caspase- 3 immunohistochemical reaction with cells positive for Ki67 with many mitotic figures. BPAL + taurine and BPAH + taurine groups showed amelioration of the previously mentioned results.

Conclusion: Taurine ameliorated the structural changes induced by BPA in the cerebral cortex of rats.

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牛磺酸对双酚:诱导的大鼠大脑皮层结构变化的可能保护作用:组织学和免疫组化研究。
简介:双酚 A(BPA)是一种化合物,已被用于许多行业,如油漆和牙科密封剂。牛磺酸是一种半必需氨基酸,具有抗氧化、抗炎和抗细胞凋亡的作用。目的:本研究旨在使用组织学和免疫组化方法评估牛磺酸对双酚 A 诱导的大鼠大脑皮层结构变化可能产生的保护作用。材料和方法:35 只 Wistar 大鼠(180-200 gm)分为对照组:10 只;I 组:5 只大鼠接受玉米油(0.5 mL/天);II 组(双酚低剂量;BPAL):5 只大鼠接受低剂量双酚 A(25 mg/kg/三次/周);III 组(双酚高剂量;BPAH):5 只大鼠接受高剂量双酚 A(100 mg/kg/三次/周);IV 组:(BPAL + 牛磺酸):5 只大鼠接受牛磺酸 100 毫克/千克/天和 BPAL(25 毫克/千克/三次/周);第五组:(双酚 AH + 牛磺酸):结果:结果:BPAL和BPAH组大鼠的神经胶质细胞、锥体细胞和神经胶质细胞在H&E染色切片中出现了明显的剂量依赖性组织学变化,GFAP、caspase-3免疫组化反应显著增加,细胞Ki67阳性,有许多有丝分裂。BPAL + 牛磺酸组和 BPAH + 牛磺酸组的上述结果有所改善:牛磺酸可改善双酚 A 诱导的大鼠大脑皮层结构变化。
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