K Koike, E Yoshida, K Katagiri, M Katayanagi, M Oda, H Tsunoo, K Yaginuma, M Kobayashi
{"title":"Production of hepatitis B virus surface antigen particles by the human hepatoma cell line huGK-14 in a serum-free medium.","authors":"K Koike, E Yoshida, K Katagiri, M Katayanagi, M Oda, H Tsunoo, K Yaginuma, M Kobayashi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The human hepatoma cell line, huGK-14, containing integrated hepatitis B virus (HBV) DNAs, produced a large number of 23 nm spherical particles of HBV surface antigen (HBsAg) in a serum-free medium. These particles closely resembled the HBsAg particles found in the sera of HBV carriers and elicited a high antibody response in guinea pigs. The huGK-14 cells in a serum-free medium would provide a new, economic source of HBV vaccine.</p>","PeriodicalId":14634,"journal":{"name":"Japanese journal of cancer research : Gann","volume":"78 12","pages":"1341-6"},"PeriodicalIF":0.0000,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of cancer research : Gann","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The human hepatoma cell line, huGK-14, containing integrated hepatitis B virus (HBV) DNAs, produced a large number of 23 nm spherical particles of HBV surface antigen (HBsAg) in a serum-free medium. These particles closely resembled the HBsAg particles found in the sera of HBV carriers and elicited a high antibody response in guinea pigs. The huGK-14 cells in a serum-free medium would provide a new, economic source of HBV vaccine.
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