Effects of physical training on hypothalamic neuronal activation and expressions of vasopressin and oxytocin in SHR after running until fatigue

Pflügers Archiv - European Journal of Physiology Pub Date : 2024-02-03 DOI:10.1007/s00424-024-02916-1

{"title":"Effects of physical training on hypothalamic neuronal activation and expressions of vasopressin and oxytocin in SHR after running until fatigue","authors":"","doi":"10.1007/s00424-024-02916-1","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>To assess the influence of physical training on neuronal activation and hypothalamic expression of vasopressin and oxytocin in spontaneously hypertensive rats (SHR), untrained and trained normotensive rats and SHR were submitted to running until fatigue while internal body and tail temperatures were recorded. Hypothalamic c-Fos expression was evaluated in thermoregulatory centers such as the median preoptic nucleus (MnPO), medial preoptic nucleus (mPOA), paraventricular nucleus of the hypothalamus (PVN), and supraoptic nucleus (SON). The PVN and the SON were also investigated for vasopressin and oxytocin expressions. Although exercise training improved the workload performed by the animals, it was reduced in SHR and followed by increased internal body temperature due to tail vasodilation deficit. Physical training enhanced c-Fos expression in the MnPO, mPOA, and PVN of both strains, and these responses were attenuated in SHR. Vasopressin immunoreactivity in the PVN was also increased by physical training to a lesser extent in SHR. The already-reduced oxytocin expression in the PVN of SHR was increased in response to physical training. Within the SON, neuronal activation and the expressions of vasopressin and oxytocin were reduced by hypertension and unaffected by physical training. The data indicate that physical training counterbalances in part the negative effect of hypertension on hypothalamic neuronal activation elicited by exercise, as well as on the expression of vasopressin and oxytocin. These hypertension features seem to negatively influence the workload performed by SHR due to the hyperthermia derived from the inability of physical training to improve heat dissipation through skin vasodilation.</p>","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pflügers Archiv - European Journal of Physiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00424-024-02916-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

To assess the influence of physical training on neuronal activation and hypothalamic expression of vasopressin and oxytocin in spontaneously hypertensive rats (SHR), untrained and trained normotensive rats and SHR were submitted to running until fatigue while internal body and tail temperatures were recorded. Hypothalamic c-Fos expression was evaluated in thermoregulatory centers such as the median preoptic nucleus (MnPO), medial preoptic nucleus (mPOA), paraventricular nucleus of the hypothalamus (PVN), and supraoptic nucleus (SON). The PVN and the SON were also investigated for vasopressin and oxytocin expressions. Although exercise training improved the workload performed by the animals, it was reduced in SHR and followed by increased internal body temperature due to tail vasodilation deficit. Physical training enhanced c-Fos expression in the MnPO, mPOA, and PVN of both strains, and these responses were attenuated in SHR. Vasopressin immunoreactivity in the PVN was also increased by physical training to a lesser extent in SHR. The already-reduced oxytocin expression in the PVN of SHR was increased in response to physical training. Within the SON, neuronal activation and the expressions of vasopressin and oxytocin were reduced by hypertension and unaffected by physical training. The data indicate that physical training counterbalances in part the negative effect of hypertension on hypothalamic neuronal activation elicited by exercise, as well as on the expression of vasopressin and oxytocin. These hypertension features seem to negatively influence the workload performed by SHR due to the hyperthermia derived from the inability of physical training to improve heat dissipation through skin vasodilation.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

体能训练对跑步至疲劳后 SHR 下丘脑神经元激活及血管加压素和催产素表达的影响

摘要为评估体能训练对自发性高血压大鼠（SHR）神经元激活及下丘脑血管加压素和催产素表达的影响，对正常血压大鼠和自发性高血压大鼠进行了跑步训练，直至疲劳为止，同时记录大鼠体内和尾部温度。评估了下丘脑c-Fos在体温调节中枢（如视前中核（MnPO）、视前内侧核（mPOA）、下丘脑室旁核（PVN）和视上核（SON））的表达。此外，还对下丘脑室旁核（PVN）和视上核（SON）的血管加压素和催产素表达进行了研究。虽然运动训练提高了动物的工作负荷，但在SHR中却降低了工作负荷，并且由于尾部血管扩张不足，体内温度随之升高。体育训练增强了两个品系的MnPO、mPOA和PVN中c-Fos的表达，而这些反应在SHR中有所减弱。体能训练也增加了PVN中的血管加压素免疫反应，但在SHR中程度较轻。SHR PVN 中已经降低的催产素表达在体能训练后有所增加。在SON内，神经元激活以及血管加压素和催产素的表达因高血压而减少，但不受体育训练的影响。这些数据表明，体育训练在一定程度上抵消了高血压对运动引起的下丘脑神经元激活以及血管加压素和催产素表达的负面影响。这些高血压特征似乎对 SHR 的工作量产生了负面影响，因为体育训练无法通过皮肤血管扩张改善散热，从而导致高热。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pflügers Archiv - European Journal of Physiology

自引率

0.00%

发文量