P4PC: A Portal for Bioinformatics Resources of piRNAs and circRNAs

IF 2.4 3区生物学 Q3 BIOCHEMICAL RESEARCH METHODS Current Bioinformatics Pub Date : 2024-02-02 DOI:10.2174/0115748936289420240117100823

Yajun Liu, Ru Li, Yulian Ding, Xin Hong Hei, Fang-Xiang Wu

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引用次数: 0

Abstract

Background: PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs) are two kinds of non-coding RNAs (ncRNAs) that play important roles in epigenetic regulation, transcriptional regulation, post-transcriptional regulation of many biological processes. Although there exist various resources, it is still challenging to select such resources for specific research projects on ncRNAs. Method: In order to facilitate researchers in finding the appropriate bioinformatics sources for studying ncRNAs, we created a novel portal named P4PC that provides computational tools and data sources of piRNAs and circRNAs. Result: 249 computational tools, 126 databases and 420 papers are manually curated in P4PC. All entries in P4PC are classified in 5 groups and 26 subgroups. The list of resources is summarized in the first page of each group Conclusion: According to their research proposes, users can quickly select proper resources for their research projects by viewing detail information and comments in P4PC. Database URL is http://www.ibiomedical.net/Portal4PC/ and http://43.138.46.5:8080/Portal4PC/.

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P4PC：piRNA 和 circRNA 生物信息学资源门户网站

背景：PIWI互作RNA（piRNA）和环状RNA（circRNA）是两种非编码RNA（ncRNA），它们在表观遗传调控、转录调控、转录后调控等多种生物过程中发挥着重要作用。虽然目前已有各种资源，但如何为特定的 ncRNA 研究项目选择这些资源仍是一项挑战。方法：为了帮助研究人员找到合适的生物信息学资源来研究 ncRNAs，我们创建了一个名为 P4PC 的新门户网站，提供 piRNAs 和 circRNAs 的计算工具和数据源。结果：P4PC 中人工编辑了 249 种计算工具、126 个数据库和 420 篇论文。P4PC 中的所有条目分为 5 组和 26 个子组。每组的第一页都有资源清单汇总结论：用户可以根据自己的研究建议，通过查看 P4PC 中的详细信息和评论，快速为自己的研究项目选择合适的资源。数据库网址为 http://www.ibiomedical.net/Portal4PC/ 和 http://43.138.46.5:8080/Portal4PC/。

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来源期刊

Current Bioinformatics 生物-生化研究方法

CiteScore

6.60

自引率

2.50%

发文量

审稿时长

>12 weeks

期刊介绍： Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth/mini-reviews, research papers and guest edited thematic issues written by leaders in the field, covering a wide range of the integration of biology with computer and information science. The journal focuses on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.